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Adiponectin and cardiac hypertrophy in acromegaly

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dc.contributor.author Gürbulak, Sabriye
dc.contributor.author Akın, Fulya
dc.contributor.author Yerlikaya, Emrah
dc.contributor.author Yaylalı, Güzin.F.
dc.contributor.author Topsakal, Şenay
dc.contributor.author Tanriverdi, Halil
dc.contributor.author Akdağ, Beyza
dc.contributor.author Kaptanoğlu, Bünyamin
dc.date.accessioned 2019-08-16T13:03:16Z
dc.date.available 2019-08-16T13:03:16Z
dc.date.issued 2016
dc.identifier.issn 18995276 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/9599
dc.description.abstract Background. Adiponectin is an adipocytes-derived hormone which has been shown to possess insulin-sensitizing, antiatherogenic, and anti-inflammatory properties. In acromegaly, the data on adiponectin is contradictory. The relationship between adiponectin levels and cardiac parameters has not been studied. Objectives. The aim of this study was to find out how adiponectin levels were affected in acromegalic patients and the relationship between adiponectin levels and cardiac parameters. Material and Methods. We included 30 subjects (15 male, 15 female), diagnosed with acromegaly and 30 healthy (10 male, 20 female) subjects. Serum glucose, insulin, GH, IGF-1 and adiponectin levels were obtained and the insulin resistance of the subjects was calculated. Echocardiographic studies of the subjects were performed. Results. We determined that adiponectin levels were significantly higher in the acromegalic group than the control group. In the acromegalic group, there was no statistically significant relation between serum adiponectin and growth hormone (GH), or insulin-like growth factor-1 (IGF-1) levels (p = 0.3, p = 0.1). We demonstrated that cardiac function and structure are affected by acromegaly. IVST, PWT, LVMI, E/A ratio, DT, ET, IVRT, VPR, and LVESV values were increased and the results were statistically significant. In the acromegalic group, adiponectin levels were positively related with left ventricle mass index (LVMI) but this correlation was found to be statistically weak (p = 0.03). In our study, there was a positive correlation between VAI and LVM. We also could not find any correlation between VAI and adiponectin levels. Conclusions. Although insulin resistance and high insulin levels occur in active acromegaly patients, adiponectin levels were higher in our study as a consequence of GH lowering therapies. Our study showed that adiponectin levels may be an indicator of the cardiac involvement acromegaly. However, the usage of serum adiponectin levels in acromegalic patients as an indicator of cardiac involvement should be supported with other, wide, multi-centered studies. © Copyright by Wroclaw Medical University.
dc.language.iso English
dc.publisher Wroclaw University of Medicine
dc.relation.isversionof 10.17219/acem/35639
dc.rights info:eu-repo/semantics/openAccess
dc.subject Acromegaly
dc.subject Adiponectin
dc.subject Cardiac hypertrophy
dc.subject Echocardiography
dc.subject Insulin resistance
dc.subject adiponectin
dc.subject growth hormone
dc.subject insulin
dc.subject somatomedin C
dc.subject ADIPOQ protein, human
dc.subject glucose blood level
dc.subject acromegaly
dc.subject adult
dc.subject Article
dc.subject cardiovascular parameters
dc.subject clinical article
dc.subject controlled study
dc.subject deceleration time
dc.subject early transmitral maximal flow velocity atrial transmitral maximal flow velocity ratio
dc.subject echocardiography
dc.subject female
dc.subject heart function
dc.subject heart left ventricle ejection fraction
dc.subject heart left ventricle enddiastolic volume
dc.subject heart left ventricle endsystolic volume
dc.subject heart left ventricle mass
dc.subject heart ventricle ejection time
dc.subject heart ventricle hypertrophy
dc.subject human
dc.subject insulin blood level
dc.subject insulin resistance
dc.subject interventricular septum thickness
dc.subject isovolumetric relaxation time
dc.subject left ventricular posterior wall thickness
dc.subject male
dc.subject predictive value
dc.subject velocity of mitral flow propagation
dc.subject analysis of variance
dc.subject blood
dc.subject blood pressure
dc.subject cardiomegaly
dc.subject intraabdominal fat
dc.subject metabolism
dc.subject middle aged
dc.subject pathophysiology
dc.subject physiology
dc.subject Adult
dc.subject Analysis of Variance
dc.subject Blood Glucose
dc.subject Blood Pressure
dc.subject Cardiomegaly
dc.subject Female
dc.subject Growth Hormone
dc.subject Humans
dc.subject Insulin
dc.subject Insulin Resistance
dc.subject Insulin-Like Growth Factor I
dc.subject Intra-Abdominal Fat
dc.subject Male
dc.subject Middle Aged
dc.title Adiponectin and cardiac hypertrophy in acromegaly
dc.type Article
dc.relation.journal Advances in Clinical and Experimental Medicine
dc.identifier.volume 25
dc.identifier.issue 3
dc.identifier.startpage 449
dc.identifier.endpage 455
dc.relation.publicationCategory Uluslararası Hakemli Dergi
dc.identifier.index Scopus
dc.identifier.index WOS
dc.identifier.index PubMed

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