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Cerebral hemodynamics in patients with cirrhosis

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dc.contributor.author Öncel, Çağatay
dc.contributor.author Yılmaz, Mustafa
dc.date.accessioned 2019-08-16T13:03:11Z
dc.date.available 2019-08-16T13:03:11Z
dc.date.issued 2016
dc.identifier.issn 13004948 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/9590
dc.description.abstract Background/Aims: Cirrhosis causes a decrease in cerebral blood flow because of a hyperdynamic circulatory state. We aimed to study the cerebral hemodynamic parameters in patients with decompensated cirrhosis and their relationship to the Child-Pugh and Model for End-Stage Liver Disease (MELD) scores. Materials and Methods: We used transcranial Doppler to investigate the cerebral hemodynamic parameters, namely the mean flow velocity of the middle cerebral artery, pulsatility index (PI), and resistive index (RI), in 50 patients who had decompensated cirrhosis and in a control group of 50 healthy people. We also investigated their relationship to the Child-Pugh and MELD scores. Results: Patients with cirrhosis had a lower mean flow velocity than those in the control group. Further, patients with cirrhosis had higher PI and RI values. There was a positive correlation between PI and the Child-Pugh score. In addition, there was a positive correlation among PI, RI, and the MELD score. The RI values of patients with ascites were higher than those of patients without ascites. Conclusion: Cerebral autoregulation might be impaired in patients with cirrhosis. Cerebral resistance proportionally increases to disease severity. There was a positive correlation among PI, RI, and MELD scores, which means that transcranial Doppler might be useful not only in the follow-up of the severity of the disease but also in determining the survival of these patients. © Copyright 2016 by The Turkish Society of Gastroenterology.
dc.language.iso English
dc.publisher Turkish Society of Gastroenterology
dc.relation.isversionof 10.5152/tjg.2016.15446
dc.rights info:eu-repo/semantics/openAccess
dc.subject Cerebral hemodynamics
dc.subject Child-Pugh
dc.subject Cirrhotic patients
dc.subject MELD score
dc.subject Transcranial Doppler
dc.subject adult
dc.subject Article
dc.subject ascites
dc.subject autoregulation
dc.subject blood flow velocity
dc.subject brain blood flow
dc.subject Child Pugh score
dc.subject clinical article
dc.subject controlled study
dc.subject decompensated liver cirrhosis
dc.subject disease duration
dc.subject disease severity
dc.subject female
dc.subject hemodynamic parameters
dc.subject human
dc.subject intracranial pressure
dc.subject male
dc.subject middle cerebral artery
dc.subject Model For End Stage Liver Disease Score
dc.subject prognosis
dc.subject survival rate
dc.subject transcranial doppler
dc.subject aged
dc.subject brain
dc.subject brain artery
dc.subject brain circulation
dc.subject case control study
dc.subject complication
dc.subject diagnostic imaging
dc.subject hemodynamics
dc.subject liver cirrhosis
dc.subject middle aged
dc.subject pathophysiology
dc.subject physiology
dc.subject procedures
dc.subject pulsatile flow
dc.subject severity of illness index
dc.subject transcranial Doppler ultrasonography
dc.subject vascularization
dc.subject Aged
dc.subject Ascites
dc.subject Blood Flow Velocity
dc.subject Brain
dc.subject Case-Control Studies
dc.subject Cerebral Arteries
dc.subject Cerebrovascular Circulation
dc.subject Female
dc.subject Hemodynamics
dc.subject Humans
dc.subject Liver Cirrhosis
dc.subject Male
dc.subject Middle Aged
dc.subject Pulsatile Flow
dc.subject Severity of Illness Index
dc.subject Ultrasonography, Doppler, Transcranial
dc.title Cerebral hemodynamics in patients with cirrhosis
dc.type Article
dc.relation.journal Turkish Journal of Gastroenterology
dc.contributor.authorID 0000-0003-3273-3068
dc.identifier.volume 27
dc.identifier.issue 3
dc.identifier.startpage 264
dc.identifier.endpage 267
dc.relation.publicationCategory Uluslararası Hakemli Dergi
dc.identifier.index Scopus
dc.identifier.index TRDizin
dc.identifier.index WOS
dc.identifier.index PubMed

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