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Mesenchymal stem cells and c-type natriuretic peptide signaling: A proposal for a new treatment approach for skeletal dysplasias

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dc.contributor.author Ünal, Murat Serkant
dc.contributor.author Tufan, Ahmet Çevik
dc.date.accessioned 2019-08-16T13:02:08Z
dc.date.available 2019-08-16T13:02:08Z
dc.date.issued 2016
dc.identifier.issn 1574888X (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/9498
dc.description.abstract Endochondral ossification is under the regulation of endocrine, paracrine and otocrine factors including transforming growth factor-β superfamily members, fibroblast growth factors, retinoids, products of hedgehog gene, parathyroid hormone-related peptide, molecules involved in cell adhesion, and extracellular matrix components. Natriuretic peptide receptor-B, and its ligand C-type natriuretic peptide have also been implicated in the regulation of limb bone development. Results of recent studies are promising in terms of systemic elevation of C-type natriuretic peptide level inducing growth. In addition, same strategy also overcomes the dwarf phenotype of achondroplasia, the most frequently seen skeletal dysplasia in human, in a mouse model. Based on this literature and a series of recent experiments discussed here, this perspective underlines the abundant C-type natriuretic peptide expression in trabecular bone derived mesenchymal stem cells of human, chicken, and rat origin, and proposes the potential use of mesenchymal stem cells as a part of growth inducing treatment strategy in osteochondrodisyplasias in the future. © 2016 Bentham Science Publishers.
dc.language.iso English
dc.publisher Bentham Science Publishers B.V.
dc.rights info:eu-repo/semantics/closedAccess
dc.subject Achondroplasia
dc.subject C-type natriuretic peptide
dc.subject Dwarfism
dc.subject Endochondral ossification
dc.subject Mesenchymal stem cells
dc.subject Natriuretic peptide receptor-B
dc.subject Osteochondrodisyplasia
dc.subject Skeletal dysplasia
dc.subject atrial natriuretic factor
dc.subject brain natriuretic peptide
dc.subject natriuretic factor
dc.subject natriuretic peptide receptor B
dc.subject natriuretic peptide type C
dc.subject achondroplasia
dc.subject Article
dc.subject bone dysplasia
dc.subject enchondral ossification
dc.subject growth rate
dc.subject human
dc.subject in vitro study
dc.subject mesenchymal stem cell
dc.subject mesenchymal stem cell transplantation
dc.subject musculoskeletal development
dc.subject nonhuman
dc.subject phenotype
dc.subject priority journal
dc.subject protein expression
dc.subject signal transduction
dc.subject tissue engineering
dc.subject trabecular bone
dc.title Mesenchymal stem cells and c-type natriuretic peptide signaling: A proposal for a new treatment approach for skeletal dysplasias
dc.type Article
dc.relation.journal Current Stem Cell Research and Therapy
dc.contributor.authorID 0000-0003-1992-7909
dc.contributor.authorID 0000-0002-5920-0475
dc.identifier.volume 11
dc.identifier.issue 6
dc.identifier.startpage 513
dc.identifier.endpage 521
dc.relation.publicationCategory Uluslararası Hakemli Dergi
dc.identifier.index Scopus
dc.identifier.index WOS

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