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Topical ketoprofen versus placebo in treatment of acute ankle sprain in the emergency department

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dc.contributor.author Serinken, Mustafa
dc.contributor.author Eken, C.
dc.contributor.author Elicabuk, H.
dc.date.accessioned 2019-08-16T13:01:31Z
dc.date.available 2019-08-16T13:01:31Z
dc.date.issued 2016
dc.identifier.issn 1071-1007
dc.identifier.uri https://hdl.handle.net/11499/9442
dc.identifier.uri https://doi.org/10.1177/1071100716650530
dc.description.abstract Background: Topical agents have been shown to be effective in soft tissue injuries and commonly used in outpatient clinics. However, the data regarding topical agents in the emergency department is insufficient, and they are not used often in the emergency department setting. The present study aimed to compare the effect of 2.5% topical ketoprofen (gel form) to placebo in patients presenting with ankle sprain to the emergency department. Methods: Patients presenting with ankle sprain composed the study population. Study patients were randomized into 2 study arms: 2.5% ketoprofen gel and placebo administered over a 5-cm area locally. Pain alleviation was measured by visual analog scale at 15 and 30 minutes. A total of 100 patients were included in the final analysis. Results: The median pain reduction in ketoprofen and placebo groups at 15 minutes was 27 (19.8-33.4) and 9 (7.6-17), respectively. The median pain reduction at 30 minutes for both groups was 42 (36-50.8) and 20 (17.6-24.4), respectively. Pain improvement either at 15 minutes (median difference: 16 [9-22]) or 30 minutes (median difference: 21 [15-27]) was better in the ketoprofen group than placebo. There were no adverse effects in either group. Conclusion: Ketoprofen gel was superior to placebo at 30 minutes in alleviating pain secondary to ankle sprain in the ED with a high safety profile. Further studies are needed concerning the effect of ketoprofen gel for long-term effects. Level of Evidence: Level I, high quality prospective randomized study. © The Author(s) 2016. en_US
dc.language.iso en en_US
dc.publisher SAGE Publications Inc. en_US
dc.relation.ispartof Foot and Ankle International en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject ankle sprain en_US
dc.subject emergency department en_US
dc.subject ketoprofen en_US
dc.subject topical en_US
dc.subject placebo en_US
dc.subject ketoprofen topical gel en_US
dc.subject nonsteroid antiinflammatory agent en_US
dc.subject absence of side effects en_US
dc.subject adult en_US
dc.subject Article en_US
dc.subject comparative effectiveness en_US
dc.subject controlled clinical trial en_US
dc.subject controlled study en_US
dc.subject double blind procedure en_US
dc.subject emergency ward en_US
dc.subject female en_US
dc.subject gel en_US
dc.subject human en_US
dc.subject intention to treat analysis en_US
dc.subject major clinical study en_US
dc.subject male en_US
dc.subject pain intensity en_US
dc.subject pain measurement en_US
dc.subject priority journal en_US
dc.subject prospective study en_US
dc.subject topical treatment en_US
dc.subject visual analog scale en_US
dc.subject analogs and derivatives en_US
dc.subject Ankle Injuries en_US
dc.subject hospital emergency service en_US
dc.subject pain en_US
dc.subject Sprains and Strains en_US
dc.subject treatment outcome en_US
dc.subject Anti-Inflammatory Agents, Non-Steroidal en_US
dc.subject Double-Blind Method en_US
dc.subject Emergency Service, Hospital en_US
dc.subject Humans en_US
dc.subject Ketoprofen en_US
dc.subject Pain en_US
dc.subject Pain Measurement en_US
dc.subject Prospective Studies en_US
dc.subject Treatment Outcome en_US
dc.title Topical ketoprofen versus placebo in treatment of acute ankle sprain in the emergency department en_US
dc.type Article en_US
dc.identifier.volume 37 en_US
dc.identifier.issue 9 en_US
dc.identifier.startpage 989
dc.identifier.startpage 989 en_US
dc.identifier.endpage 993 en_US
dc.identifier.doi 10.1177/1071100716650530
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.identifier.pmid 27198132 en_US
dc.identifier.scopus 2-s2.0-84986218222 en_US
dc.identifier.wos WOS:000382971600012 en_US


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