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Effect of concentrated growth factor on survival of diced cartilage graft

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dc.contributor.author Topkara, Adem
dc.contributor.author Özkan, Adem
dc.contributor.author Özcan, Ramazan Hakan
dc.contributor.author Öksüz, M.
dc.contributor.author Akbulut, M.
dc.date.accessioned 2019-08-16T13:00:22Z
dc.date.available 2019-08-16T13:00:22Z
dc.date.issued 2016
dc.identifier.issn 1090820X (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/9376
dc.description.abstract Background Diced cartilage grafts are important in rhinoplasty for raising the dorsum and eliminating dorsal irregularities. The most common problems with the use of diced cartilage are wrapping and cartilage resorption. Objectives To histopathologically investigate and compare the viability of diced cartilage grafts wrapped with concentrated growth factor, fascia and fenestrated fascia, or blood glue. Methods Cartilage grafts were harvested from the ears of 10 New Zealand White rabbits and diced into 0.5 to 1 mm3 pieces. The grafts were divided into five groups for comparison: (1) bare diced cartilage; (2) diced cartilage wrapped with fascia; (3) diced cartilage wrapped with fenestrated fascia; (4) diced cartilage wrapped with concentrated growth factor (CGF); and (5) diced cartilage wrapped with blood glue. Each of the five grafts was autologously implanted into a subcutaneous pocket in the back of each rabbit. Three months later, the rabbits were sacrificed and the implants were harvested and examined histopathologically. Results Nucleus loss, calcification, inflammation, and giant cell formation differed significantly between the CGF group and both fascia groups. Chondrocyte proliferation was the highest in the CGF group. Nucleus loss rates were similar between the fascia and fenestrated fascia groups. Conclusions Our findings suggest that CGF improves the viability of diced cartilage grafts, while fascia hampers it. Punching holes in the fascia does not improve diced cartilage graft viability and neither does blood glue wrapping. © copyright Crown 2016.
dc.language.iso English
dc.publisher Oxford University Press
dc.relation.isversionof 10.1093/asj/sjw137
dc.rights info:eu-repo/semantics/openAccess
dc.subject biomaterial
dc.subject blood glue
dc.subject concentrated growth factor
dc.subject glue
dc.subject growth factor
dc.subject unclassified drug
dc.subject fibrin glue
dc.subject signal peptide
dc.subject animal experiment
dc.subject animal tissue
dc.subject Article
dc.subject bone regeneration
dc.subject calcification
dc.subject cartilage cell
dc.subject cartilage graft
dc.subject cell loss
dc.subject cell nucleus
dc.subject cell proliferation
dc.subject cell viability
dc.subject chondrogenesis
dc.subject chondrolysis
dc.subject controlled study
dc.subject diced cartilage graft
dc.subject fascia
dc.subject fenestrated fascia
dc.subject giant cell
dc.subject graft survival
dc.subject histopathology
dc.subject inflammation
dc.subject male
dc.subject New Zealand White (rabbit)
dc.subject nonhuman
dc.subject priority journal
dc.subject tissue differentiation
dc.subject tissue engineering
dc.subject animal
dc.subject autotransplantation
dc.subject back muscle
dc.subject blood
dc.subject cartilage
dc.subject comparative study
dc.subject drug effects
dc.subject pathology
dc.subject procedures
dc.subject rabbit
dc.subject time factor
dc.subject tissue survival
dc.subject transplantation
dc.subject Animals
dc.subject Back Muscles
dc.subject Cartilage
dc.subject Fibrin Tissue Adhesive
dc.subject Graft Survival
dc.subject Intercellular Signaling Peptides and Proteins
dc.subject Male
dc.subject Rabbits
dc.subject Time Factors
dc.subject Tissue and Organ Harvesting
dc.subject Tissue Survival
dc.subject Transplantation, Autologous
dc.title Effect of concentrated growth factor on survival of diced cartilage graft
dc.type Article
dc.relation.journal Aesthetic Surgery Journal
dc.identifier.volume 36
dc.identifier.issue 10
dc.identifier.startpage 1176
dc.identifier.endpage 1187
dc.relation.publicationCategory Uluslararası Hakemli Dergi
dc.identifier.index Scopus
dc.identifier.index WOS
dc.identifier.index PubMed


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