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Diagnostic Capability of Peripapillary Retinal Volume Measurements in Glaucoma

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dc.contributor.author Simavlı, Hüseyin
dc.contributor.author Poon, L.Y.-C.
dc.contributor.author Que, C.J.
dc.contributor.author Liu, Y.
dc.contributor.author Akduman, M.
dc.contributor.author Tsikata, E.
dc.contributor.author De Boer, J.F.
dc.contributor.author Chen, T.C.
dc.date.accessioned 2019-08-16T12:59:42Z
dc.date.available 2019-08-16T12:59:42Z
dc.date.issued 2017
dc.identifier.issn 10570829 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/9310
dc.description.abstract Purpose: To determine the diagnostic capability of spectral domain optical coherence tomography peripapillary retinal volume (RV) measurements. Materials and Methods: A total of 156 patients, 89 primary open-angle glaucoma and 67 normal subjects, were recruited. Spectral domain optical coherence tomography peripapillary RV was calculated for 4 quadrants using 3 annuli of varying scan circle diameters: outer circumpapillary annuli of circular grids 1, 2, and 3 (OCA1, OCA2, OCA3). Area under the receiver operating characteristic curves and pairwise comparisons of receiver operating characteristic (ROC) curves were performed to determine which quadrants were best for diagnosing primary open-angle glaucoma. The pairwise comparisons of the best ROC curves for RV and retinal nerve fiber layer (RNFL) were performed. The artifact rates were analyzed. Results: Pairwise comparisons showed that the smaller annuli OCA1 and OCA2 had better diagnostic performance than the largest annulus OCA3 (P<0.05 for all quadrants). OCA1 and OCA2 had similar diagnostic performance, except for the inferior quadrant which was better for OCA1 (P=0.0033). The pairwise comparisons of the best ROC curves for RV and RNFL were not statistically significant. RV measurements had lower rates of artifacts at 7.4% while RNFL measurements had higher rates at 42.9%. Conclusions: Peripapillary RV measurements have excellent ability for diagnosing not only glaucoma patients but also a subset of early glaucoma patients. The inferior quadrant of peripapillary annulus OCA1 demonstrated the best diagnostic capability for both glaucoma and early glaucoma. The diagnostic ability of RV is comparable with that of RNFL parameters in glaucoma but with lower artifact rates. © 2017 Wolters Kluwer Health, Inc. All rights reserved.
dc.language.iso English
dc.publisher Lippincott Williams and Wilkins
dc.relation.isversionof 10.1097/IJG.0000000000000621
dc.rights info:eu-repo/semantics/openAccess
dc.subject glaucoma
dc.subject optical coherence tomography
dc.subject peripapillary
dc.subject retinal nerve fiber layer thickness
dc.subject retinal thickness
dc.subject adult
dc.subject area under the curve
dc.subject Article
dc.subject artifact
dc.subject controlled study
dc.subject diagnostic accuracy
dc.subject diagnostic test
dc.subject eye examination
dc.subject eye refraction
dc.subject Goldmann applanation tonometer
dc.subject gonioscopy
dc.subject human
dc.subject image reconstruction
dc.subject major clinical study
dc.subject open angle glaucoma
dc.subject ophthalmoscopy
dc.subject optical coherence tomography device
dc.subject pachymetry
dc.subject priority journal
dc.subject receiver operating characteristic
dc.subject reproducibility
dc.subject retina ganglion cell
dc.subject sensitivity and specificity
dc.subject single photon emission computed tomography
dc.subject slit lamp microscopy
dc.subject visual acuity
dc.subject aged
dc.subject diagnostic imaging
dc.subject female
dc.subject male
dc.subject middle aged
dc.subject nerve fiber
dc.subject pathology
dc.subject predictive value
dc.subject procedures
dc.subject retina
dc.subject Adult
dc.subject Aged
dc.subject Area Under Curve
dc.subject Female
dc.subject Glaucoma
dc.subject Glaucoma, Open-Angle
dc.subject Humans
dc.subject Male
dc.subject Middle Aged
dc.subject Nerve Fibers
dc.subject Predictive Value of Tests
dc.subject Retina
dc.subject Retinal Ganglion Cells
dc.subject ROC Curve
dc.subject Sensitivity and Specificity
dc.subject Tomography, Optical Coherence
dc.title Diagnostic Capability of Peripapillary Retinal Volume Measurements in Glaucoma
dc.type Article
dc.relation.journal Journal of Glaucoma
dc.contributor.authorID 0000-0003-1657-9099
dc.identifier.volume 26
dc.identifier.issue 6
dc.identifier.startpage 592
dc.identifier.endpage 601
dc.relation.publicationCategory Uluslararası Hakemli Dergi
dc.identifier.index Scopus
dc.identifier.index WOS
dc.identifier.index PubMed


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