DSpace Repository

Effects of curcumin on alveolar bone loss in experimental periodontitis in rats: A morphometric and histopathologic study

Show simple item record

dc.contributor.author Akpinar, A.
dc.contributor.author Calisir, M.
dc.contributor.author Karakan, N.C.
dc.contributor.author Alpan, A.L.
dc.contributor.author Goze, F.
dc.contributor.author Poyraz, O.
dc.date.accessioned 2019-08-16T12:59:35Z
dc.date.available 2019-08-16T12:59:35Z
dc.date.issued 2017
dc.identifier.issn 03009831 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/9302
dc.description.abstract Background: Curcumin is found in the rhizomes of the turmeric plant that has been showed antioxidant and anti-inflammatory effect. The aim of this study was to evaluate the effects of systemic curcumin therapy on alveolar bone loss in an experimental periodontitis model in rats. Material and Methods: Thirty-two male Wistar rats were randomly divided to 4 groups: 75 mg/kg/daily curcumin (C75; n=8), 150 mg/kg/ daily curcumin (C150; n=8), Control (n=8), and Ligated (n=8). Curcumin was administrated using gastric gavage. After 12 days, the rats were sacrificed. Right mandibles samples were histopathologically examined. Alveolar bone loss was measured. Interleukin 1β (IL-1β) and interleukin 10 (IL-10) were evaluated in the serum samples and gingival homogenates. Results: The measurements of alveolar bone loss in the mandibular molars revealed significantly higher bone-loss values in the Ligated group than the Control, C75 and C150 groups. The IL-1β levels in the gingival homogenates were significantly increased in the Ligated group compared to those of the Control, C75 and C150 groups. The serum IL-1β levels in the Ligated group were significantly higher than the Control group. The mean osteoblast numbers in the Ligated group were lower than those of the Control, C75 and C150 groups. The C150 groups showed significantly more osteoblasts than the Control group. The osteoclast numbers in the Ligated group increased significantly compared to the C75, C150 and control groups. Conclusion: This study demonstrates that systemic administration of curcumin at the 75 and 150mg/kg doses reduced alveolar bone loss in the periodontal disease in rats. © 2018 Hogrefe.
dc.language.iso English
dc.publisher Verlag Hans Huber AG
dc.relation.isversionof 10.1024/0300-9831/a000243
dc.subject Alveolar bone loss
dc.subject Antioxidant
dc.subject Curcumin
dc.subject Histomorphometric
dc.subject Ligature-induced
dc.subject Micronutrition
dc.title Effects of curcumin on alveolar bone loss in experimental periodontitis in rats: A morphometric and histopathologic study
dc.type Article
dc.relation.journal International Journal for Vitamin and Nutrition Research
dc.identifier.volume 87
dc.identifier.issue 5-6
dc.identifier.startpage 262
dc.identifier.endpage 270
dc.identifier.index Scopus


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record