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Relationship between Fragmented QRS Complex and Aortic Stiffness in Chronic Hemodialysis Patients

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dc.contributor.author Güçlü, A.
dc.contributor.author Nar, G.
dc.contributor.author Içli, A.
dc.contributor.author Özhan, Nail
dc.contributor.author Sezer, S.
dc.date.accessioned 2019-08-16T12:59:35Z
dc.date.available 2019-08-16T12:59:35Z
dc.date.issued 2017
dc.identifier.issn 10117571 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/9301
dc.description.abstract Objective: This study aimed to evaluate the correlation between fragmented QRS complex (fQRS), aortic stiffness, and diastolic dysfunction in hemodialysis patients. Subjects and Methods: A sample of 56 patients who received hemodialysis treatment was stratified into 2 groups according to their electrocardiography (ECG) patterns with or without fQRS. Baseline characteristics and laboratory parameters of patients were documented. Conventional echocardiographic and Doppler echocardiographic procedures were performed in all patients. The mean early (Em) diastolic and late (Am) diastolic myocardial velocities were calculated. These tests were performed before dialysis. The Student t test, Mann-Whitney U test, χ2 test, Spearman correlation, and multivariate linear regression analysis were used to analyze parameters where appropriate. Results: Of the 56 patients under hemodialysis, fQRS in ECG was detected in 26 (46.4%). Echocardiographic evaluation showed that deceleration time (237.57 ± 40.10 ms; p = 0.030), isovolumic relaxation time (126.84 ± 15.62 ms; p < 0.001), early (E)/late (A) ventricular filling velocity (E/A) ratio (1.15 ± 0.40; p ≤ 0.001), and aortic stiffness index value (9.62 ± 4.53; p = 0.016) exhibited a statistical increase in hemodialysis patients with fQRS compared to patients without fQRS. E (58.23 ± 19.96 m/s; p = 0.004), and Em (5.96 ± 2.08 cm/s; p = 0.023) velocity levels were significantly lower in hemodialysis patients with fQRS than patients without fQRS. Aortic stiffness closely correlated with diastolic dysfunction (deceleration time r = 0.273, p = 0.042; isovolumic relaxation time r = 0.497, p < 0.001; E/A ratio r = -0.449, p = 0.001). On multivariate linear regression analysis, fQRS and aortic stiffness were independently associated in hemodialysis patients (β = 0.321, p = 0.049). Conclusions: Increased aortic stiffness and left ventricular systolic dysfunction were observed more frequently in hemodialysis patients with fQRS than in patients without fQRS. fQRS is an important determinant of aortic stiffness in hemodialysis patients. © 2016 S. Karger AG, Basel.
dc.language.iso English
dc.publisher S. Karger AG
dc.relation.isversionof 10.1159/000452418
dc.rights info:eu-repo/semantics/openAccess
dc.rights info:eu-repo/semantics/openAccess
dc.subject Aortic stiffness
dc.subject Diastolic dysfunction
dc.subject Fragmented QRS complex
dc.subject Hemodialysis
dc.subject albumin
dc.subject angiotensin receptor antagonist
dc.subject antilipemic agent
dc.subject beta adrenergic receptor blocking agent
dc.subject C reactive protein
dc.subject calcium
dc.subject cholesterol
dc.subject creatinine
dc.subject dipeptidyl carboxypeptidase inhibitor
dc.subject erythropoietin
dc.subject ferritin
dc.subject glucose
dc.subject hemoglobin
dc.subject high density lipoprotein
dc.subject low density lipoprotein
dc.subject parathyroid hormone
dc.subject phosphate binding agent
dc.subject phosphorus
dc.subject triacylglycerol
dc.subject urea
dc.subject uric acid
dc.subject vitamin D
dc.subject adult
dc.subject aged
dc.subject albumin blood level
dc.subject aortic stiffness index
dc.subject arterial stiffness
dc.subject Article
dc.subject calcium blood level
dc.subject cardiovascular parameters
dc.subject cholesterol blood level
dc.subject chronic kidney failure
dc.subject controlled study
dc.subject creatinine blood level
dc.subject deceleration
dc.subject diastolic dysfunction
dc.subject Doppler echocardiography
dc.subject electrocardiography
dc.subject female
dc.subject ferritin blood level
dc.subject fragmented qrs complex
dc.subject glucose blood level
dc.subject heart left ventricle filling
dc.subject hemodialysis
dc.subject hemodialysis patient
dc.subject hemoglobin blood level
dc.subject human
dc.subject lipoprotein blood level
dc.subject major clinical study
dc.subject male
dc.subject medical documentation
dc.subject parathyroid hormone blood level
dc.subject phosphate blood level
dc.subject protein blood level
dc.subject QRS complex
dc.subject relaxation time
dc.subject triacylglycerol blood level
dc.subject urea blood level
dc.subject uric acid blood level
dc.subject chronic disease
dc.subject comparative study
dc.subject complication
dc.subject echocardiography
dc.subject heart left ventricle function
dc.subject middle aged
dc.subject pathophysiology
dc.subject physiology
dc.subject Renal Insufficiency, Chronic
dc.subject statistical model
dc.subject Turkey
dc.subject Adult
dc.subject Aged
dc.subject Chronic Disease
dc.subject Echocardiography
dc.subject Electrocardiography
dc.subject Female
dc.subject Humans
dc.subject Linear Models
dc.subject Male
dc.subject Middle Aged
dc.subject Renal Dialysis
dc.subject Vascular Stiffness
dc.subject Ventricular Dysfunction, Left
dc.title Relationship between Fragmented QRS Complex and Aortic Stiffness in Chronic Hemodialysis Patients
dc.type Article
dc.relation.journal Medical Principles and Practice
dc.identifier.volume 26
dc.identifier.issue 1
dc.identifier.startpage 66
dc.identifier.endpage 70
dc.relation.publicationCategory Uluslararası Hakemli Dergi
dc.identifier.index Scopus
dc.identifier.index WOS
dc.identifier.index PubMed


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