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Serum leptin levels and GHR-d3/fl gene polymorphism in acromegalic patients with thyroid nodules

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dc.contributor.author Topsakal, S.
dc.contributor.author Akin, F.
dc.contributor.author Turgut, S.
dc.contributor.author Yerlikaya, E.
dc.contributor.author Yaylali, G.F.
dc.date.accessioned 2019-08-16T12:58:14Z
dc.date.available 2019-08-16T12:58:14Z
dc.date.issued 2017
dc.identifier.issn 18995276 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/9085
dc.description.abstract Background. Acromegaly is a rare and serious syndrome that is commonly associated with pituitary neoplasms. Thyroid multinodular disease is a common finding in acromegaly. Leptin is a polypeptide hormone, and studies have shown that it can increase cell proliferation and inhibit apoptosis. Objectives. The aim of the study was to determine the relationship of serum leptin levels with certain blood parameters and determine if growth hormone receptor (GHR)-d3/fl gene polymorphism is associated with thyroid nodules in acromegalic patients. Material and methods. A total of 24 acromegalic patients with or without thyroid nodules were included in the study. Gene polymorphisms and blood parameters were examined. Results. A marked increase was observed in serum leptin concentration in acromegalic patients with thyroid nodules compared to patients without them (p < 0.05). GH levels were lower in patients without nodules than in patients with nodules (p < 0.05). Blood glucose levels were higher in patients with nodules compared to those without them (p < 0.05), and the presence of thyroid nodules was associated with decreased blood low-density lipoprotein (LDL) levels compared to patients without nodules (p < 0.05). A significant relationship was observed between growth hormone receptor (GHR)-d3/fl gene polymorphism and leptin levels in acromegalic patients with thyroid nodules (p < 0.001). Conclusions. These data from acromegalic patients indicate that thyroid nodules are associated with increased serum leptin, GH and blood glucose levels and with decreased LDL levels. GHR-d3/fl gene polymorphism status was strongly related to higher leptin levels. Copyright © 2017 by Wroclaw Medical University.
dc.language.iso English
dc.publisher Wroclaw University of Medicine
dc.relation.isversionof 10.17219/acem/34793
dc.rights info:eu-repo/semantics/openAccess
dc.subject Acromegaly
dc.subject Endocrinology
dc.subject Gene polymorphism
dc.subject Hormone
dc.subject Thyroid
dc.subject alkaline phosphatase
dc.subject calcium
dc.subject glucose
dc.subject growth hormone
dc.subject growth hormone receptor
dc.subject high density lipoprotein cholesterol
dc.subject leptin
dc.subject liothyronine
dc.subject low density lipoprotein cholesterol
dc.subject phosphorus
dc.subject prolactin
dc.subject somatomedin binding protein 3
dc.subject somatomedin C
dc.subject thyrotropin
dc.subject thyroxine
dc.subject triacylglycerol
dc.subject glucose blood level
dc.subject human growth hormone
dc.subject low density lipoprotein
dc.subject acromegaly
dc.subject adult
dc.subject aged
dc.subject anthropometry
dc.subject Article
dc.subject blood chemistry
dc.subject blood pressure measurement
dc.subject body height
dc.subject body mass
dc.subject clinical article
dc.subject DNA polymorphism
dc.subject female
dc.subject free liothyronine index
dc.subject free thyroxine index
dc.subject genetic analysis
dc.subject genotype
dc.subject homeostasis model assessment
dc.subject human
dc.subject immunoassay
dc.subject laboratory test
dc.subject male
dc.subject nuclear magnetic resonance imaging
dc.subject polymerase chain reaction
dc.subject thyroid nodule
dc.subject blood
dc.subject complication
dc.subject exon
dc.subject gene deletion
dc.subject gene frequency
dc.subject genetic polymorphism
dc.subject genetics
dc.subject metabolism
dc.subject middle aged
dc.subject very elderly
dc.subject young adult
dc.subject Adult
dc.subject Aged
dc.subject Aged, 80 and over
dc.subject Blood Glucose
dc.subject Exons
dc.subject Female
dc.subject Gene Deletion
dc.subject Gene Frequency
dc.subject Genotype
dc.subject Human Growth Hormone
dc.subject Humans
dc.subject Leptin
dc.subject Lipoproteins, LDL
dc.subject Male
dc.subject Middle Aged
dc.subject Polymorphism, Genetic
dc.subject Receptors, Somatotropin
dc.subject Thyroid Nodule
dc.subject Young Adult
dc.title Serum leptin levels and GHR-d3/fl gene polymorphism in acromegalic patients with thyroid nodules
dc.type Article
dc.relation.journal Advances in Clinical and Experimental Medicine
dc.identifier.volume 26
dc.identifier.issue 2
dc.identifier.startpage 281
dc.identifier.endpage 286
dc.identifier.index Scopus


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