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Assessment of optic disc and ganglion cell layer in diabetes mellitus type 2

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dc.contributor.author Pekel, E.
dc.contributor.author Tufaner, G.
dc.contributor.author Kaya, H.
dc.contributor.author Kaşikçi, A.
dc.contributor.author Deda, G.
dc.contributor.author Pekel, Gökhan
dc.date.accessioned 2019-08-16T12:57:47Z
dc.date.available 2019-08-16T12:57:47Z
dc.date.issued 2017
dc.identifier.issn 00257974 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/8984
dc.description.abstract The purpose of this study was to compare the optic disc parameters, retinal nerve fiber (RNFL), and macular ganglion cell layers between patients with diabetes mellitus (DM) type 2 and healthy controls. In this cross-sectional study, 69 eyes of 69 diabetic patients without diabetic retinopathy and 47 eyes of 47 healthy controls were included. Optic disc parameters (i.e., rim area, disc area, cup to disc ratio, cup volume), RNFL, and macular ganglion cell-inner plexiform layers (GCL+IPL) thickness were measured by means of spectral domain optical coherence tomography. There were not statistically significant differences between the diabetic patients and healthy controls in terms of RNFL thickness (P=.32), rim area (P=.20), disc area (P=.16), cup volume (P=.12), and average macular GCL+IPL thickness (P=.11). Nevertheless, binocular RNFL thickness symmetry percentage (P=.03), average cup to disc ratio (P=.02), and superior-nasal macular GCL+IPL thickness (P=.04) were statistically significantly different in the diabetic and control groups. Diabetic patients without retinopathy have more binocular RNFL thickness asymmetry, higher cup to disc ratio, and thinner sectoral macular GCL+IPL when compared to healthy controls. Our results may support the statement that DM causes inner retinal neurodegenerative changes. © 2017 the Author(s). Published by Wolters Kluwer Health, Inc.
dc.language.iso English
dc.publisher Lippincott Williams and Wilkins
dc.relation.isversionof 10.1097/MD.0000000000007556
dc.rights info:eu-repo/semantics/openAccess
dc.rights info:eu-repo/semantics/openAccess
dc.subject diabetes mellitus
dc.subject HbA1c
dc.subject macular ganglion cell layer
dc.subject optic disc
dc.subject retinal nerve fiber layer
dc.subject hemoglobin A1c
dc.subject adult
dc.subject aged
dc.subject Article
dc.subject binocular vision
dc.subject controlled study
dc.subject cross-sectional study
dc.subject diabetic patient
dc.subject diabetic retinopathy
dc.subject disease duration
dc.subject female
dc.subject hemoglobin blood level
dc.subject human
dc.subject macular thickness
dc.subject major clinical study
dc.subject male
dc.subject non insulin dependent diabetes mellitus
dc.subject optic disk
dc.subject optical coherence tomography device
dc.subject priority journal
dc.subject retina ganglion cell
dc.subject retinal nerve fiber layer thickness
dc.subject spectral domain optical coherence tomography
dc.subject comparative study
dc.subject diagnostic imaging
dc.subject middle aged
dc.subject optical coherence tomography
dc.subject organ size
dc.subject Adult
dc.subject Aged
dc.subject Cross-Sectional Studies
dc.subject Diabetes Mellitus, Type 2
dc.subject Diabetic Retinopathy
dc.subject Female
dc.subject Humans
dc.subject Male
dc.subject Middle Aged
dc.subject Optic Disk
dc.subject Organ Size
dc.subject Retinal Ganglion Cells
dc.subject Tomography, Optical Coherence
dc.title Assessment of optic disc and ganglion cell layer in diabetes mellitus type 2
dc.type Article
dc.relation.journal Medicine (United States)
dc.identifier.volume 96
dc.identifier.issue 29
dc.relation.publicationCategory Uluslararası Hakemli Dergi
dc.identifier.index Scopus
dc.identifier.index WOS
dc.identifier.index PubMed


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