DSpace Repository

The growth hormone receptor polymorphism in patients with acromegaly: Relationship to BMI and glucose metabolism

Show simple item record

dc.contributor.author Turgut, Sebahat
dc.contributor.author Akın, Fulya
dc.contributor.author Ayada, Ceylan
dc.contributor.author Topsakal, Şenay
dc.contributor.author Yerlikaya, Emrah
dc.contributor.author Turgut, Günfer
dc.date.accessioned 2019-08-16T12:46:00Z
dc.date.available 2019-08-16T12:46:00Z
dc.date.issued 2012
dc.identifier.issn 1386341X (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/8730
dc.description.abstract The aim of this study was to investigate association between the frequencies of Growth Hormone receptor (d3GHR) gene polymorphisms and some clinical parameters of acromegalic patients. Total of 35 acromegalic patients were enrolled to study. The d3GHR polymorphism was identified by using polymerase chain reaction from peripheral blood samples. The levels of systolic and diastolic blood pressure, BMI, fasting plasma glucose (FPG), Fasting insulin, HOMA-IR, IGF-I, GH, IGFBP3, triglyceride, HDL and LDL cholesterol concentrations were evaluated. The frequencies of d3GHR genotypes were found as follows; 5 (14.3%) subjects had d3/d3, 11 (31.4%) had d3/fl and 19 (54.3%) had fl/fl in patients. The prevalence of the d3 and fl alleles was 30 and 70%, respectively. Systolic blood pressure, fasting insulin and HOMA-IR was found significantly increased in homozygote d3GHR genotype group compared to d3/fl subjects (P\0.05). In addition, BMI was observed significantly different among three genotypes (P = 0.007) and in the subjects with d3/d3 genotype, BMI was found significantly higher than d3/fl and fl/fl genotypes groups. As well as, no significant difference was found between the d3 and fl alleles group in terms of the clinical parameters except for BMI (P = 0.002). It can be said that the d3GHR gene polymorphism may affect BMI, systolic blood pressure and insulin regulation. At the same time we can say homozygote d3GHR genotype and d3 allele carriers may have more risk than other genotypes for high BMI. © Springer Science+Business Media, LLC 2011.
dc.language.iso English
dc.publisher Springer New York LLC
dc.relation.isversionof 10.1007/s11102-011-0329-9
dc.rights info:eu-repo/semantics/closedAccess
dc.subject Acromegaly
dc.subject BMI
dc.subject d3GHR polymorphism
dc.subject IGF-I
dc.subject Insulin
dc.subject glitazone derivative
dc.subject glucose
dc.subject growth hormone
dc.subject growth hormone receptor
dc.subject high density lipoprotein cholesterol
dc.subject insulin
dc.subject low density lipoprotein cholesterol
dc.subject metformin
dc.subject somatomedin binding protein 3
dc.subject somatomedin C
dc.subject somatostatin derivative
dc.subject triacylglycerol
dc.subject acromegaly
dc.subject adult
dc.subject allele
dc.subject article
dc.subject blood sampling
dc.subject body mass
dc.subject clinical article
dc.subject diastolic blood pressure
dc.subject disease association
dc.subject DNA polymorphism
dc.subject female
dc.subject genetic risk
dc.subject genotype
dc.subject glucose blood level
dc.subject glucose metabolism
dc.subject heterozygote
dc.subject homozygote
dc.subject human
dc.subject insulin resistance
dc.subject male
dc.subject polymerase chain reaction
dc.subject prevalence
dc.subject priority journal
dc.subject systolic blood pressure
dc.title The growth hormone receptor polymorphism in patients with acromegaly: Relationship to BMI and glucose metabolism
dc.type Article
dc.relation.journal Pituitary
dc.contributor.authorID 0000-0002-7884-5623
dc.contributor.authorID 0000-0002-6272-4173
dc.contributor.authorID 0000-0003-4575-5653
dc.identifier.volume 15
dc.identifier.issue 3
dc.identifier.startpage 374
dc.identifier.endpage 379
dc.relation.publicationCategory Uluslararası Hakemli Dergi
dc.identifier.index Scopus
dc.identifier.index WOS
dc.identifier.index PubMed

Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record