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Investigation of cartilage degradation in patients with spinal cord injury by CTX-II

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dc.contributor.author Fındıkoğlu, Gülin
dc.contributor.author Gunduz, B.
dc.contributor.author Uzun, Hasibe
dc.contributor.author Erhan, B.
dc.contributor.author Rota, Simin
dc.contributor.author Ardıç, Füsun
dc.date.accessioned 2019-08-16T12:45:19Z
dc.date.available 2019-08-16T12:45:19Z
dc.date.issued 2012
dc.identifier.issn 13624393 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/8700
dc.description.abstract Study design:Clinical cross-sectional study. Objectives: To investigate the cartilage degradation by turnover of C-telopeptide fragments of collagen type-II (CTX-II), a molecule specific for articular cartilage in spinal cord injured patients with respect to clinical functional status. Setting: Physical Medicine and Rehabilitation Clinics, hospital settings. Methods: In 68 patients with spinal cord injury (SCI) level and severity of lesion, duration of disease, American Spinal Injury Association Impairment Scale (AIS), motor and sensory score, presence of spasticity, functional ambulation score (FAS) and duration of daily ambulation were evaluated. Cartilage degradation was demonstrated by urinary CTX-II (uCTX-II) measured by enzyme-linked immunosorbent assay. T test, analysis of variance and Pearson correlation analysis were used for statistical calculations. Results: uCTX-II level was significantly higher in patients with AIS grade A, non-functional ambulators or in patients who did not ambulate at all (P<0.05). Although AIS grade, lower extremity motor score, FAS score and duration of daily ambulation were found to be correlated (P<0.05) with uCTX-II, duration of disease, level of neurological lesion, presence of spasticity were not. Conclusion: This is the first study providing evidence that cartilage degradation is associated with elevated uCTX-II levels in non-ambulating or non-functional ambulating SCI patients. AIS grade A, FAS zero score and no time for daily ambulation were found to cause significant differences in CTX-II level. It may be important to initiate therapeutic programs as soon as possible after SCI to prevent cartilage atrophy. © 2012 International Spinal Cord Society All rights reserved.
dc.language.iso English
dc.relation.isversionof 10.1038/sc.2011.102
dc.rights info:eu-repo/semantics/openAccess
dc.subject biomarkers
dc.subject cartilage
dc.subject CTX-II
dc.subject immobilization
dc.subject osteoarthritis
dc.subject spinal cord injury
dc.subject biological marker
dc.subject collagen type 2
dc.subject adult
dc.subject aged
dc.subject article
dc.subject articular cartilage
dc.subject cartilage degeneration
dc.subject cross-sectional study
dc.subject disease duration
dc.subject enzyme linked immunosorbent assay
dc.subject female
dc.subject human
dc.subject major clinical study
dc.subject male
dc.subject priority journal
dc.subject urine level
dc.subject Adult
dc.subject Aged
dc.subject Cartilage
dc.subject Cartilage, Articular
dc.subject Collagen Type II
dc.subject Cross-Sectional Studies
dc.subject Female
dc.subject Humans
dc.subject Male
dc.subject Middle Aged
dc.subject Peptide Fragments
dc.subject Severity of Illness Index
dc.subject Spinal Cord Injuries
dc.subject Walking
dc.subject Young Adult
dc.title Investigation of cartilage degradation in patients with spinal cord injury by CTX-II
dc.type Article
dc.relation.journal Spinal Cord
dc.contributor.authorID 0000-0002-7431-2918
dc.contributor.authorID 0000-0002-4708-9378
dc.identifier.volume 50
dc.identifier.issue 2
dc.identifier.startpage 136
dc.identifier.endpage 140
dc.relation.publicationCategory Uluslararası Hakemli Dergi
dc.identifier.index Scopus
dc.identifier.index WOS
dc.identifier.index PubMed

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