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Infliximab therapy for familial Mediterranean fever-related amyloidosis: Case series with long term follow-up

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dc.contributor.author Özçakar, Z.B.
dc.contributor.author Yüksel, S.
dc.contributor.author Ekim, M.
dc.contributor.author Yalçinkaya, F.
dc.date.accessioned 2019-08-16T12:41:54Z
dc.date.available 2019-08-16T12:41:54Z
dc.date.issued 2012
dc.identifier.issn 07703198 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/8528
dc.description.abstract Familial Mediterranean fever (FMF) is an autosomal recessive disease characterized by recurrent selflimited attacks of fever and polyserositis. Reactive amyloid A amyloidosis is the most devastating complication of FMF, and amyloidosis continues to occur in the colchicine era in untreated and noncompliant patients. Unfortunately, there is no proven effective treatment for established amyloidosis. In this report, we present four FMF-related amyloidosis patients that were treated with long term infliximab therapy with the longest duration of follow-up, together with the literature review. Infliximab was very effective in controlling gastrointestinal system findings and protracted arthritis, and it also had a favorable impact on the clinical findings of nephrotic syndrome in these patients. In conclusion, by controlling debilitating complaints of amyloidosis with infliximab, quality of life increases in these patients, and they get rid of recurrent hospitalizations and return to school or work. © Clinical Rheumatology 2012.
dc.language.iso English
dc.relation.isversionof 10.1007/s10067-012-2009-1
dc.subject Amyloidosis
dc.subject Familial Mediterranean fever
dc.subject Infliximab
dc.subject Pediatric
dc.subject adalimumab
dc.subject albumin
dc.subject amyloid A protein
dc.subject colchicine
dc.subject creatinine
dc.subject digoxin
dc.subject etanercept
dc.subject infliximab
dc.subject isoniazid
dc.subject phosphorus
dc.subject potassium
dc.subject recombinant interleukin 1 receptor blocking agent
dc.subject abdominal pain
dc.subject adolescent
dc.subject amyloidosis
dc.subject anaphylaxis
dc.subject appendix perforation
dc.subject arthralgia
dc.subject arthritis
dc.subject case report
dc.subject child
dc.subject clinical feature
dc.subject consciousness disorder
dc.subject diarrhea
dc.subject drug efficacy
dc.subject drug substitution
dc.subject drug withdrawal
dc.subject electrolyte disturbance
dc.subject face edema
dc.subject familial Mediterranean fever
dc.subject female
dc.subject fever
dc.subject follow up
dc.subject gastrointestinal biopsy
dc.subject gastrointestinal symptom
dc.subject heart amyloidosis
dc.subject hemodialysis
dc.subject hepatitis C
dc.subject hospitalization
dc.subject human
dc.subject human tissue
dc.subject hypoalbuminemia
dc.subject hypotension
dc.subject infection
dc.subject joint swelling
dc.subject kidney amyloidosis
dc.subject kidney biopsy
dc.subject kidney dysfunction
dc.subject kidney transplantation
dc.subject leg edema
dc.subject long term care
dc.subject male
dc.subject malnutrition
dc.subject medical literature
dc.subject nephrotic syndrome
dc.subject nutritional intolerance
dc.subject pallor
dc.subject priority journal
dc.subject proteinuria
dc.subject quality of life
dc.subject remission
dc.subject review
dc.subject school
dc.subject school child
dc.subject supplementation
dc.subject thorax pain
dc.subject total parenteral nutrition
dc.subject treatment outcome
dc.subject vomiting
dc.subject work resumption
dc.subject Adolescent
dc.subject Anti-Inflammatory Agents, Non-Steroidal
dc.subject Antibodies, Monoclonal
dc.subject Child
dc.subject Colchicine
dc.subject Drug Therapy, Combination
dc.subject Familial Mediterranean Fever
dc.subject Female
dc.subject Follow-Up Studies
dc.subject Gout Suppressants
dc.subject Humans
dc.subject Male
dc.subject Treatment Outcome
dc.title Infliximab therapy for familial Mediterranean fever-related amyloidosis: Case series with long term follow-up
dc.type Review
dc.relation.journal Clinical Rheumatology
dc.identifier.volume 31
dc.identifier.issue 8
dc.identifier.startpage 1267
dc.identifier.endpage 1271
dc.identifier.index Scopus


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