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The Synergistic effect of fotemustine and genistein on expressions of p53, EGFR and COX-2 genes in human glioblastoma multiforme cell line

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dc.contributor.author Avci, C.B.
dc.contributor.author Dodurga, Y.
dc.contributor.author Oktar, N.
dc.contributor.author Yilmaz Süslüer, S.
dc.contributor.author Doǧan Şiǧva, Z.O.
dc.contributor.author Gündüz, C.
dc.date.accessioned 2019-08-16T12:40:29Z
dc.date.available 2019-08-16T12:40:29Z
dc.date.issued 2012
dc.identifier.issn 13001817 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/8444
dc.description.abstract GBM is the most common primary malignant neoplasm of the central nervous system in adults. Fotemustine (FTM) is a cytotoxic alkylating agent and a lipophilic chloroethylnitrosourea derivative. Its mechanism of action consists mainly in inducing DNA strand breaks and cross-linking. Genistein, one of the soy-derived isoflavones, exerts its anticancer properties via several mechanisms, including inhibition of tyrosine phosphorylation, weak estrogenic and anti-estrogenic properties, as an antioxidant, inhibition of topoisomerase II, inhibition of angiogenesis, and induction of cell differentiation in a number of human tumors. We aimed to investigate the anti-proliferative synergistic effect of genistein with fotemustine on human glioblastoma multiforme U87-MG cells. This study was also designed to answer the following question: Do the p53, EGFR, COX-2 genes' expression patterns differ in treatment of these both drugs alone and in combination?
dc.language.iso English; Turkish
dc.subject COX-2
dc.subject EGFR
dc.subject Fotemustine
dc.subject Genistein
dc.subject p53
dc.subject U-87MG
dc.subject cyclooxygenase 2
dc.subject epidermal growth factor receptor
dc.subject fotemustine
dc.subject genistein
dc.subject protein p53
dc.subject antiproliferative activity
dc.subject article
dc.subject cell viability
dc.subject concentration response
dc.subject controlled study
dc.subject Cox 2 gene
dc.subject cytotoxicity
dc.subject drug effect
dc.subject drug potentiation
dc.subject EGFR gene
dc.subject gene
dc.subject gene expression
dc.subject gene expression profiling
dc.subject glioblastoma
dc.subject glioma cell
dc.subject human
dc.subject human cell
dc.subject IC 50
dc.subject real time polymerase chain reaction
dc.subject reverse transcription polymerase chain reaction
dc.subject tumor suppressor gene
dc.title The Synergistic effect of fotemustine and genistein on expressions of p53, EGFR and COX-2 genes in human glioblastoma multiforme cell line
dc.type Article
dc.relation.journal Journal of Neurological Sciences
dc.identifier.volume 29
dc.identifier.issue 3
dc.identifier.startpage 510
dc.identifier.endpage 517
dc.identifier.index Scopus

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