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Isolation of Scedosporium apiospermum (Teleomorph: Pseudallescheria apiospermd) from an acute myeloid leukemia patient

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dc.contributor.author Ergin, Çağrı
dc.contributor.author Kutlu, Murat
dc.contributor.author Arikan Akdaǧli, S.
dc.contributor.author Saribaş, Z.
dc.contributor.author Aydeniz Ozansoy, Fatma
dc.contributor.author Sari, İsmail
dc.contributor.author Dursunoǧlu, Neşe
dc.date.accessioned 2019-08-16T12:36:13Z
dc.date.available 2019-08-16T12:36:13Z
dc.date.issued 2013
dc.identifier.issn 03749096 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/8154
dc.description.abstract Scedosporium apiospermum is an emerging opportunistic pathogen that may lead to life-threatening infections especially in immunosuppressive individuals. In this report, S.apiospermum infection in a 62 year old male patient with acute myeloid leukemia was presented. During remission-induction chemotherapy, piperacillin-tazobactam therapy was started for febrile neutropenia. Since fever had continued, treatment was switched to imipenem and also amphotericin B deoxycholate was added to the treatment protocol. Because of allergic reaction to amphotericin B, caspofungin was started at the fifth day of neutropenic fever. Following imaging studies with high resolution computerized thorasic tomography, antifungal therapy was changed to voriconazole due to findings suggestive of invasive aspergillosis. Since galactomannan antigen was found negative at the first day of voriconazole therapy, bronchoalveolar lavage material from apical segment of the left lower lobe was cultured onto various microbiologic media. S.apiospermum (Teleomorph: Pseudallescheria apiosperma) was isolated on the fourth day of cultivation. According to CLSI M38-A2 microdilution procedure, minimum inhibitory concentrations (MIC) of voriconazole, caspofungin, amphotericin B and posaconazole were found as 0.06, 2, 8 and 4 μg/ml, respectively. Since neutropenia was resolved, the patient was discharged with continued voriconazole therapy. It was concluded that antifungal susceptibility tests should be performed for Scedosporium species and the results should be compared to the clinical response. The determination of MIC breakpoints may provide useful information for the recommendation and use of optimal choices for the treatment of Scedosporium infections.
dc.language.iso Turkish
dc.relation.isversionof 10.5578/mb.4655
dc.rights info:eu-repo/semantics/openAccess
dc.subject Acute myeloid leukemia
dc.subject Antifungal susceptibility
dc.subject Pseudallescheria apiosperma
dc.subject Scedosporium apiospermum
dc.subject antifungal agent
dc.subject caspofungin
dc.subject echinocandin
dc.subject pyrimidine derivative
dc.subject triazole derivative
dc.subject voriconazole
dc.subject acute granulocytic leukemia
dc.subject article
dc.subject case report
dc.subject human
dc.subject isolation and purification
dc.subject lung
dc.subject lung lavage
dc.subject male
dc.subject microbiology
dc.subject middle aged
dc.subject mycosis
dc.subject neutropenia
dc.subject opportunistic infection
dc.subject Pseudallescheria
dc.subject Scedosporium
dc.subject Antifungal Agents
dc.subject Bronchoalveolar Lavage Fluid
dc.subject Echinocandins
dc.subject Humans
dc.subject Leukemia, Myeloid, Acute
dc.subject Lung
dc.subject Male
dc.subject Middle Aged
dc.subject Mycoses
dc.subject Neutropenia
dc.subject Opportunistic Infections
dc.subject Pyrimidines
dc.subject Triazoles
dc.title Isolation of Scedosporium apiospermum (Teleomorph: Pseudallescheria apiospermd) from an acute myeloid leukemia patient
dc.title.alternative Bir akut miyeloid lösemi hastasından scedosporium apiospermum (Teleomorf: Pseudallescheria apiospermd) izolasyonu
dc.type Article
dc.relation.journal Mikrobiyoloji Bulteni
dc.contributor.authorID :0000-0001-7783-8723
dc.contributor.authorID 0000-0003-0640-1019
dc.contributor.authorID :0000-0002-6323-3456
dc.identifier.volume 47
dc.identifier.issue 2
dc.identifier.startpage 351
dc.identifier.endpage 355
dc.relation.publicationCategory Uluslararası Hakemli Dergi
dc.identifier.index Scopus
dc.identifier.index PubMed
dc.identifier.index WOS


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