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Therapeutic plasma exchange in patients with neurological diseases: Multicenter retrospective analysis

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dc.contributor.author Kaya, E.
dc.contributor.author Keklik, M.
dc.contributor.author Şencan, M.
dc.contributor.author Yilmaz, M.
dc.contributor.author Keskin, Ali
dc.contributor.author Kiki, T.
dc.contributor.author Erkurt, M.A.
dc.contributor.author Şivgin, S.
dc.contributor.author Korkmaz, S.
dc.contributor.author Okan, V.
dc.contributor.author Doǧu, Mehmet Hilmi
dc.contributor.author Ünal, A.
dc.contributor.author Çetin, M.
dc.contributor.author Altuntaş, F.
dc.contributor.author Ilhan, O.
dc.date.accessioned 2019-08-16T12:35:33Z
dc.date.available 2019-08-16T12:35:33Z
dc.date.issued 2013
dc.identifier.issn 14730502 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/8107
dc.description.abstract Therapeutic plasma exchange (TPE), is a procedure, changing pathologic substances in the plasma of patients with replacement fluid. TPE has an increasing list of indications in recent years such as neurological, connective tissue, hematological, nephrological, endocrinological and metabolic disorders. We report our multicenter data about therapeutic plasma exchange in patients with neurological diseases. Six University Hospitals' aphaeresis units medical records about neurologic diseases were reviewed retrospectively. Hundred and fifteen patients and 771 TPE sessions from six aphaeresis units' were included to this study. Of the 115 patients, 53 (46%) were men and 62 (54%) were women. The median age was 50 (range: 5-85) years. Of these patients 58.3% were Guillain-Barre syndrome (GBS), 17.4% were acute disseminated encephalomyelitis (ADEM), 10.4% were chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), 7% were multiple sclerosis, 6.1% were myasthenia gravis (MG) and 0.9% were Wilson disease (WD). The median number of TPE sessions per patient was 5 (range 1-72). Human albumin was used as a replacement fluid in 66% and fresh frozen plasma was used in 34% of cases. TPE was done through central venous catheters in 66%, and peripheral venous access in 34% of patients. Some complications were seen in patients (18.3%) during TPE sessions. These complications were, complications related to catheter placement procedure (8.7%), hypotension (3.5%), hypocalcaemia (3.5%) and allergic reactions (1.7%). The complication ratios were 2.7% in total 771 TPE procedures. TPE procedure was terminated in 6% of sessions depending on these complications. Overall responses to TPE were noted in 89.5% of patients.In conclusion; Therapeutic plasma exchange is an effective treatment option in several neurologic diseases. © 2013 Elsevier Ltd.
dc.language.iso English
dc.relation.isversionof 10.1016/j.transci.2013.04.015
dc.rights info:eu-repo/semantics/closedAccess
dc.subject Acute disseminated encephalomyelitis
dc.subject Chronic inflammatory demyelinating polyradiculoneuropathy
dc.subject Guillain-Barre syndrome
dc.subject Multiple sclerosis
dc.subject Myasthenia gravis
dc.subject Therapeutic plasma exchange
dc.subject fresh frozen plasma
dc.subject human albumin
dc.subject acute disseminated encephalomyelitis
dc.subject adolescent
dc.subject adult
dc.subject aged
dc.subject allergic reaction
dc.subject article
dc.subject catheter complication
dc.subject central venous catheter
dc.subject child
dc.subject female
dc.subject Guillain Barre syndrome
dc.subject human
dc.subject hypocalcemia
dc.subject hypotension
dc.subject major clinical study
dc.subject male
dc.subject medical record review
dc.subject multicenter study
dc.subject multiple sclerosis
dc.subject myasthenia gravis
dc.subject neurologic disease
dc.subject peripheral venous catheter
dc.subject plasmapheresis
dc.subject polyradiculoneuropathy
dc.subject preschool child
dc.subject retrospective study
dc.subject school child
dc.subject tachycardia
dc.subject university hospital
dc.subject Wilson disease
dc.subject Adolescent
dc.subject Adult
dc.subject Aged
dc.subject Aged, 80 and over
dc.subject Albumins
dc.subject Blood Component Removal
dc.subject Child
dc.subject Child, Preschool
dc.subject Encephalomyelitis, Acute Disseminated
dc.subject Female
dc.subject Guillain-Barre Syndrome
dc.subject Humans
dc.subject Male
dc.subject Middle Aged
dc.subject Multiple Sclerosis
dc.subject Myasthenia Gravis
dc.subject Plasma Exchange
dc.subject Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
dc.subject Retrospective Studies
dc.subject Treatment Outcome
dc.subject Young Adult
dc.title Therapeutic plasma exchange in patients with neurological diseases: Multicenter retrospective analysis
dc.type Article
dc.relation.journal Transfusion and Apheresis Science
dc.identifier.volume 48
dc.identifier.issue 3
dc.identifier.startpage 349
dc.identifier.endpage 352
dc.relation.publicationCategory Uluslararası Hakemli Dergi
dc.identifier.index Scopus
dc.identifier.index WOS


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