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Non-invasive detection of biliary leaks using Gd-EOB-DTPA-enhanced MR cholangiography: Comparison with T2-weighted MR cholangiography

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dc.contributor.author Kantarci, M.
dc.contributor.author Pirimoglu, B.
dc.contributor.author Karabulut, Nevzat
dc.contributor.author Bayraktutan, U.
dc.contributor.author Ogul, H.
dc.contributor.author Ozturk, G.
dc.contributor.author Aydinli, B.
dc.contributor.author Kizrak, Y.
dc.contributor.author Eren, S.
dc.contributor.author Yilmaz, S.
dc.date.accessioned 2019-08-16T12:33:57Z
dc.date.available 2019-08-16T12:33:57Z
dc.date.issued 2013
dc.identifier.issn 09387994 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/7974
dc.description.abstract Objective: To evaluate the added role of T1-weighted (T1w) gadolinium ethoxybenzyl diethylenetriamine penta-acetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance cholangiography (MRC) compared with T2-weighted MRC (T2w-MRC) in the detection of biliary leaks. Methods: Ninety-nine patients with suspected biliary complications underwent routine T2w-MRC and T1w contrast-enhanced (CE) MRC using Gd-EOB-DTPA to identify biliary leaks. Two observers reviewed the image sets separately and together. MRC findings were compared with those of surgery and percutaneous transhepatic cholangiopancreatography. The sensitivity, specificity and accuracy of the techniques in identifying biliary leaks were calculated. Results: Accuracy of locating biliary leaks was superior with the combination of Gd-EOB-DTPA-enhanced MRC and T2w-MRC (P < 0.05).The mean sensitivities were 79 % vs 59 %, and the mean accuracy rates were 84 % vs 58 % for combined CE-MRC and T2w-MRC vs sole T2w-MRC. Nineteen out of 21 patients with biliary-cyst communication, 90.4 %, and 12/15 patients with post-traumatic biliary extravasations, 80 %, were detected by the combination of Gd-EOB-DTPA-enhanced MRC and T2w-MRC images, P < 0.05. Conclusions: Gd-EOB-DTPA-enhanced MRC yields information that complements T2w-MRC findings and improves the identification and localisation of the bile extravasations (84 % accuracy, 100 % specificity, P < 0.05). We recommend Gd-EOB-DTPA-enhanced MRC in addition to T2w-MRC to increase the preoperative accuracy of identifying and locating extravasations of bile. Key Points: • Magnetic resonance cholangiography (MRC) does not always detect bile leakage and cysto-biliary communications. • Gd-EOB-DTPA-enhanced MRC helps by demonstrating extravasation of contrast material into fluid collections. • Gd-EOB-DTPA-enhanced MRC also demonstrates the leakage site and bile duct injury type. • Combined Gd-EOB-DTPA-enhanced and T2w-MRC can provide comprehensive information about biliary system. • Gd-EOB-DTPA-enhanced MRC is non-invasive and does not use ionising radiation. © 2013 The Author(s).
dc.language.iso English
dc.relation.isversionof 10.1007/s00330-013-2880-4
dc.rights info:eu-repo/semantics/openAccess
dc.subject Biliary leaks
dc.subject Biliary tree
dc.subject Contrast enhanced MRC
dc.subject Gd-EOB-DTPA
dc.subject MR cholangiography
dc.subject gadoxetic acid
dc.subject adult
dc.subject aged
dc.subject article
dc.subject bile leakage
dc.subject cholangiography
dc.subject clinical trial
dc.subject diagnostic accuracy
dc.subject diagnostic test accuracy study
dc.subject diagnostic value
dc.subject endoscopic retrograde cholangiopancreatography
dc.subject female
dc.subject human
dc.subject magnetic resonance cholangiography
dc.subject major clinical study
dc.subject male
dc.subject non invasive procedure
dc.subject postoperative complication
dc.subject priority journal
dc.subject sensitivity and specificity
dc.subject Adult
dc.subject Aged
dc.subject Anastomotic Leak
dc.subject Biliary Tract Diseases
dc.subject Cholangiopancreatography, Magnetic Resonance
dc.subject Contrast Media
dc.subject Diffusion Magnetic Resonance Imaging
dc.subject Gadolinium DTPA
dc.subject Humans
dc.subject Image Enhancement
dc.subject Image Interpretation, Computer-Assisted
dc.subject Male
dc.subject Middle Aged
dc.subject Reproducibility of Results
dc.subject Sensitivity and Specificity
dc.title Non-invasive detection of biliary leaks using Gd-EOB-DTPA-enhanced MR cholangiography: Comparison with T2-weighted MR cholangiography
dc.type Article
dc.relation.journal European Radiology
dc.contributor.authorID 0000-0002-0822-0281
dc.identifier.volume 23
dc.identifier.issue 10
dc.identifier.startpage 2713
dc.identifier.endpage 2722
dc.relation.publicationCategory Uluslararası Hakemli Dergi
dc.identifier.index Scopus
dc.identifier.index WOS
dc.identifier.index PubMed

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