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Injection of specific amyloid-beta oligomers (beta1-40:Beta1-42510:1) into rat medial septum impairs memory retention without inducing hippocampal apoptosis

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dc.contributor.author Özdemir, M.B.
dc.contributor.author Erdogan, C.
dc.contributor.author Iwasaki, K.
dc.contributor.author Watanabe, T.
dc.contributor.author Ishikane, S.
dc.contributor.author Fujiwara, M.
dc.date.accessioned 2019-08-16T12:33:54Z
dc.date.available 2019-08-16T12:33:54Z
dc.date.issued 2013
dc.identifier.issn 01616412 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/7967
dc.description.abstract Objectives: Because of the well-known neurochemical interactions between the septum and hippocampus during memory processes, we investigated the effect of amyloid-beta (A-beta) injection into the medial septum (MS) on the behavior in Wistar rats. We also assessed whether the observed effects were functional or due to apoptosis. Methods: Specific A-beta oligomers (beta1-40:beta1-42 510:1) were injected into MS for seven consecutive days. Behavior was assessed with the Morris water maze task. Results: Compared with the control group, rats that received A-beta oligomers exhibited significant memory retention impairment (P < 0.05) without apoptosis in the cornu ammonis (CA)1 and CA3 regions of the dorsal hippocampus. Discussion: These data indicate that septal injection of A-beta impairs memory retention, even in the absence of hippocampal apoptosis. This result might bring new insight to spatial memory-related disorders like Alzheimer's disease (AD). © W. S. Maney & Son Ltd 2013.
dc.language.iso English
dc.relation.isversionof 10.1179/1743132813Y.0000000195
dc.subject A-beta
dc.subject Apoptosis
dc.subject Medial septal area
dc.subject Memory retention
dc.subject Water maze
dc.subject amyloid beta protein [1-40]
dc.subject amyloid beta protein [1-42]
dc.subject unclassified drug
dc.subject animal behavior
dc.subject animal experiment
dc.subject animal tissue
dc.subject apoptosis
dc.subject article
dc.subject controlled study
dc.subject forced swimming test
dc.subject hippocampal CA1 region
dc.subject hippocampal CA3 region
dc.subject hippocampus
dc.subject male
dc.subject memory disorder
dc.subject nerve function
dc.subject nick end labeling
dc.subject nonhuman
dc.subject rat
dc.subject septum nucleus
dc.subject spatial memory
dc.subject stereotactic procedure
dc.subject Amyloid beta-Peptides
dc.subject Animals
dc.subject CA1 Region, Hippocampal
dc.subject CA3 Region, Hippocampal
dc.subject Male
dc.subject Maze Learning
dc.subject Microinjections
dc.subject Peptide Fragments
dc.subject Rats
dc.subject Retention (Psychology)
dc.subject Septum of Brain
dc.title Injection of specific amyloid-beta oligomers (beta1-40:Beta1-42510:1) into rat medial septum impairs memory retention without inducing hippocampal apoptosis
dc.type Article
dc.relation.journal Neurological Research
dc.identifier.volume 35
dc.identifier.issue 8
dc.identifier.startpage 798
dc.identifier.endpage 803
dc.identifier.index Scopus


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