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Neutrophil-to-lymphocyte ratio may predict subclinical atherosclerosis in patients with psoriasis

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dc.contributor.author Yurtdaş, M.
dc.contributor.author Yaylalı, Yalın Tolga
dc.contributor.author Kaya, Y.
dc.contributor.author Özdemir, M.
dc.contributor.author Özkan, I.
dc.contributor.author Alada?, N.
dc.date.accessioned 2019-08-16T12:32:11Z
dc.date.available 2019-08-16T12:32:11Z
dc.date.issued 2014
dc.identifier.issn 0742-2822
dc.identifier.uri https://hdl.handle.net/11499/7797
dc.identifier.uri https://doi.org/10.1111/echo.12511
dc.description.abstract Background: Systemic inflammation beyond the skin may provide an explanation of the increased cardiovascular risk observed in psoriasis. It was hypothesized that neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are potential predictors of subclinical atherosclerosis measured by aortic velocity propagation (AVP) and carotid intima-media thickness (CIMT) in psoriasis. Methods: Fifty-one patients with psoriasis taking no antipsoriatic therapy and 37 age- and sex-matched healthy controls were prospectively enrolled. The Psoriasis Area and Severity Index (PASI) was calculated. Complete blood counts were obtained. Measurements of AVP and CIMT were performed. Results: The baseline clinical and demographic features, and white blood cell, platelet, neutrophil, lymphocyte, monocyte, and PLR were similar in both groups. NLR and high-sensitivity C-reactive protein (hs-CRP) were higher in the psoriasis group than the control group (P = 0.001, P < 0.001; respectively). The psoriasis group had lower AVP and higher CIMT values than those of controls (AVP: 48.9 ± 18.1 vs. 64.3 ± 14.5 cm/sec; P < 0.001, CIMT: 0.84 ± 0.29 vs. 0.63 ± 0.27 mm; P = 0.001, respectively). PASI was positively correlated with NLR and hs-CRP (r = 0.423, P = 0.002; r = 0.315, P = 0.024, respectively). There was an inverse association between AVP and CIMT (r = -0.749, P < 0.001). Binary logistic regression analysis demonstrated that NLR was the only variable able to predict lower AVP (?41 cm/sec) and higher CIMT (>0.9 mm) values (P = 0.024 and 0.023; respectively). Conclusion: NLR is potentially an unrecognized predictor of subclinical atherosclerosis in patients with psoriasis. Future studies assessing the prognostic significance of NLR on cardiovascular event rates in psoriasis patients would be of great interest. (Echocardiography 2014;31:1095-1104). © 2014, Wiley Periodicals, Inc. en_US
dc.language.iso en en_US
dc.publisher Blackwell Publishing Inc. en_US
dc.relation.ispartof Echocardiography en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Atherosclerosis en_US
dc.subject Inflammation en_US
dc.subject Intima-media thickness en_US
dc.subject Propagation velocity en_US
dc.subject Psoriasis en_US
dc.subject C reactive protein en_US
dc.subject adult en_US
dc.subject aorta flow en_US
dc.subject Article en_US
dc.subject atherosclerosis en_US
dc.subject blood cell count en_US
dc.subject carotid artery en_US
dc.subject controlled study en_US
dc.subject female en_US
dc.subject human en_US
dc.subject leukocyte en_US
dc.subject lymphocyte en_US
dc.subject major clinical study en_US
dc.subject male en_US
dc.subject monocyte en_US
dc.subject neutrophil en_US
dc.subject neutrophil lymphocyte ratio en_US
dc.subject platelet lymphocyte ratio en_US
dc.subject psoriasis en_US
dc.subject Psoriasis Area and Severity Index en_US
dc.subject thrombocyte en_US
dc.subject aorta en_US
dc.subject arterial pressure en_US
dc.subject arterial wall thickness en_US
dc.subject blood en_US
dc.subject complication en_US
dc.subject echography en_US
dc.subject heart ventricle en_US
dc.subject middle aged en_US
dc.subject procedures en_US
dc.subject prospective study en_US
dc.subject randomized controlled trial en_US
dc.subject reproducibility en_US
dc.subject risk assessment en_US
dc.subject severity of illness index en_US
dc.subject statistics and numerical data en_US
dc.subject young adult en_US
dc.subject Adult en_US
dc.subject Aorta en_US
dc.subject Arterial Pressure en_US
dc.subject C-Reactive Protein en_US
dc.subject Carotid Intima-Media Thickness en_US
dc.subject Female en_US
dc.subject Heart Ventricles en_US
dc.subject Humans en_US
dc.subject Lymphocytes en_US
dc.subject Male en_US
dc.subject Middle Aged en_US
dc.subject Neutrophils en_US
dc.subject Prospective Studies en_US
dc.subject Reproducibility of Results en_US
dc.subject Risk Assessment en_US
dc.subject Severity of Illness Index en_US
dc.subject Young Adult en_US
dc.title Neutrophil-to-lymphocyte ratio may predict subclinical atherosclerosis in patients with psoriasis en_US
dc.type Article en_US
dc.identifier.volume 31 en_US
dc.identifier.issue 9 en_US
dc.identifier.startpage 1095
dc.identifier.startpage 1095 en_US
dc.identifier.endpage 1104 en_US
dc.identifier.doi 10.1111/echo.12511
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.identifier.pmid 24447343 en_US
dc.identifier.scopus 2-s2.0-84908246390 en_US
dc.identifier.wos WOS:000342827700017 en_US

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