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Evaluation of frequency and the attacks features of patients with colchicine resistance in FMF

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dc.contributor.author Cetin, G.Y.
dc.contributor.author Balkarli, A.
dc.contributor.author Öksüz, A.N.
dc.contributor.author Kimyon, G.
dc.contributor.author Pehlivan, Y.
dc.contributor.author Orhan, O.
dc.contributor.author Kisacik, B.
dc.contributor.author Cobankara, V.
dc.contributor.author Sayarlioglu, H.
dc.contributor.author Onat, A.M.
dc.contributor.author Sayarlioglu, M.
dc.date.accessioned 2019-08-16T12:32:08Z
dc.date.available 2019-08-16T12:32:08Z
dc.date.issued 2014
dc.identifier.issn 04825004 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/7790
dc.description.abstract Introduction: Colchicine is the mainstay for the treatment of FMF, which is an auto-inflammatory disease mainly with relapsing polyserositis. Despite daily doses of 2 mg ormore each day, approximately 5% to 10% of the patients continue to suffer from its attacks. In this study, we aimed to investigate the depression and attack features in patients withFMF who have colchicine resistance (CR).Patients e Methods: CR was defined for FMF patients with 2 or more attacks within the last6 months period while using 2 mg/day colchicine. Eighteen patients (9 Female/9 Male) wereenrolled into the CR group and 41 patients were enrolled into the control group (12 Male/29Female). Demographic, clinical e laboratory findings, treatment adherence, and the BeckDepression Inventory (BDI) scores were evaluated. Results: The age of onset of FMF was significantly lower in the CR group (12.3 yrs vs. 16.9 yrs, P = 0.03). Disease duration was longer in the CR group (P = 0.01). Abdominal and leg pain dueto exercise were significantly more frequent in the CR group versus controls (83% vs. 51%;P = 0.02 e 88% vs. 60%; P = 0.04, respectively). Patients with BDI scores over 17 points weremore frequent in the CR group compared to controls (50% vs. 34.1%; P < 0.001).Discussion: We found that: (1) the age of disease onset was lower and (2) the disease durationwas longer in CR group. Pleuritic attacks, hematuria e proteinuria were more frequent in CRpatients. We propose that depression is an important factor to consider in the susceptibilityto CR. © 2014 Elsevier Editora Ltda.
dc.language.iso English
dc.publisher Elsevier Editora Ltda
dc.relation.isversionof 10.1016/j.rbre.2014.03.022
dc.subject Colchicine resistance
dc.subject Depression
dc.subject Familial mediterranean fever
dc.subject Treatment
dc.subject colchicine
dc.subject abdominal pain
dc.subject adolescent
dc.subject amyloidosis
dc.subject arthritis
dc.subject Article
dc.subject Beck Depression Inventory
dc.subject child
dc.subject clinical feature
dc.subject controlled study
dc.subject depression
dc.subject disease duration
dc.subject erythema
dc.subject familial Mediterranean fever
dc.subject female
dc.subject hematuria
dc.subject human
dc.subject leg pain
dc.subject major clinical study
dc.subject male
dc.subject medication compliance
dc.subject onset age
dc.subject patient compliance
dc.subject proteinuria
dc.subject school child
dc.subject thorax pain
dc.subject adult
dc.subject complication
dc.subject drug resistance
dc.subject prospective study
dc.subject Adult
dc.subject Colchicine
dc.subject Drug Resistance
dc.subject Familial Mediterranean Fever
dc.subject Female
dc.subject Humans
dc.subject Male
dc.subject Prospective Studies
dc.title Evaluation of frequency and the attacks features of patients with colchicine resistance in FMF
dc.type Article
dc.relation.journal Revista Brasileira de Reumatologia
dc.identifier.volume 54
dc.identifier.issue 5
dc.identifier.startpage 356
dc.identifier.endpage 359
dc.identifier.index Scopus


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