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Heart rate recovery after exercise and its relation with neutrophil-to-lymphocyte ratio in patients with cardiac syndrome X

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dc.contributor.author Yurtdaş, M.
dc.contributor.author Yaylali, Y.T.
dc.contributor.author Aladaǧ, N.
dc.contributor.author Özdemir, M.
dc.contributor.author Ceylan, Y.
dc.contributor.author Gençaslan, M.
dc.contributor.author Akbulut, T.
dc.date.accessioned 2019-08-16T12:31:48Z
dc.date.available 2019-08-16T12:31:48Z
dc.date.issued 2014
dc.identifier.issn 09546928 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/7754
dc.description.abstract OBJECTIVES: The neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) are measures of systemic inflammation. Heart rate recovery (HRR) after exercise is influenced by autonomic function. The aim of this study was to ascertain whether HRR and the Duke Treadmill Score (DTS) values are related to NLR and PLR in patients with cardiac syndrome X (CSX). METHODS: A total of 350 participants were enrolled in the study. Complete blood counts and high-sensitivity C-reactive protein (hsCRP) were obtained. All participants underwent an exercise test. HRR and DTS were calculated after exercise. Abnormal HRR was defined as 12 beats/min or less. RESULTS: CSX and coronary artery disease (CAD) groups had higher NLR, PLR, and hsCRP, and lower HRR and DTS values than the control group (for all, P<0.05). In both CSX and CAD groups, HRR was positively correlated with DTS (r=0.468, P<0.001 and r=0.491, P<0.001, respectively) and negatively correlated with NLR (r=-0.519, P<0.001 and r=-0.612, P<0.001, respectively), PLR (r=-0.422, P<0.001 and r=-0.438, P<0.001, respectively), and hsCRP (r=-0.553, P<0.001 and r=-0.521, P<0.001, respectively). NLR and hsCRP were important two predictors of the presence of lower HRR in both CSX [NLR: odds ratio (OR), 0.395; 95% confidence interval (CI), 0.168-0.925; P=0.032 and hsCRP: OR, 0.748; 95% CI, 0.591-0.945; P=0.015], and CAD groups (NLR: OR, 0.115; 95% CI, 0.026-0.501; P=0.004 and hsCRP: OR, 0.637; 95% CI, 0.455-0.892; P=0.009). CONCLUSION: CSX patients have higher NLR and PLR and slower HRR and lower DTS, similar to CAD patients, suggesting that CSX patients may be at a higher risk for developing cardiovascular events in the future. NLR may predict autonomic imbalance assessed by HRR in CSX.
dc.language.iso English
dc.publisher Lippincott Williams and Wilkins
dc.relation.isversionof 10.1097/MCA.0000000000000110
dc.subject C reactive protein
dc.subject biological marker
dc.subject adult
dc.subject article
dc.subject blood cell count
dc.subject cardiac patient
dc.subject cardiovascular parameters
dc.subject cardiovascular risk
dc.subject controlled study
dc.subject coronary artery disease
dc.subject duke treadmill score
dc.subject exercise recovery
dc.subject exercise test
dc.subject female
dc.subject heart rate
dc.subject heart rate recovery
dc.subject hematological parameters
dc.subject high risk patient
dc.subject human
dc.subject major clinical study
dc.subject male
dc.subject middle aged
dc.subject neutrophil to lymphocyte ratio
dc.subject platelet to lymphocyte ratio
dc.subject predictive value
dc.subject priority journal
dc.subject scoring system
dc.subject syndrome X
dc.subject treadmill exercise
dc.subject angiocardiography
dc.subject autonomic nervous system
dc.subject blood
dc.subject chi square distribution
dc.subject comparative study
dc.subject convalescence
dc.subject exercise
dc.subject lymphocyte
dc.subject lymphocyte count
dc.subject metabolism
dc.subject Microvascular Angina
dc.subject neutrophil
dc.subject pathophysiology
dc.subject prospective study
dc.subject risk
dc.subject risk factor
dc.subject statistical model
dc.subject time
dc.subject Adult
dc.subject Autonomic Nervous System
dc.subject Biological Markers
dc.subject C-Reactive Protein
dc.subject Chi-Square Distribution
dc.subject Coronary Angiography
dc.subject Coronary Artery Disease
dc.subject Exercise
dc.subject Exercise Test
dc.subject Heart Rate
dc.subject Humans
dc.subject Logistic Models
dc.subject Lymphocyte Count
dc.subject Lymphocytes
dc.subject Middle Aged
dc.subject Neutrophils
dc.subject Odds Ratio
dc.subject Predictive Value of Tests
dc.subject Prospective Studies
dc.subject Recovery of Function
dc.subject Risk Factors
dc.subject Time Factors
dc.title Heart rate recovery after exercise and its relation with neutrophil-to-lymphocyte ratio in patients with cardiac syndrome X
dc.type Article
dc.relation.journal Coronary Artery Disease
dc.identifier.volume 25
dc.identifier.issue 6
dc.identifier.startpage 485
dc.identifier.endpage 492
dc.identifier.index Scopus


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