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Electrospun thermoplastic polyurethane mats containing naproxen- cyclodextrin inclusion complex

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dc.contributor.author Akduman, Çiğdem
dc.contributor.author Özgüney, I.
dc.contributor.author Perrin Akçakoca Kumbasar, E.
dc.date.accessioned 2019-08-16T12:31:01Z
dc.date.available 2019-08-16T12:31:01Z
dc.date.issued 2014
dc.identifier.issn 1470-9589
dc.identifier.uri https://hdl.handle.net/11499/7638
dc.identifier.uri https://doi.org/10.2478/aut-2014-0024
dc.description.abstract Incorporation of cyclodextrins (CDs) into electrospun nanofibrous materials can be considered as potential candidates for functional medical textile applications. Naproxen (NAP) is a type of non-steroidal anti-inflammatory drug commonly administered for the treatment of pain, inflammation and fever. Drug-inclusion complex formation with CDs is an approach to improve the aqueous solubility via molecular encapsulation of the drug within the cavity of the more soluble CD molecule. In this study, NAP or different NAP-CD inclusion complexes loaded nanofibres were successfully produced through electrospinning and characterised. The inclusion complex loaded mats exhibited significantly faster release profiles than NAP-loaded thermoplastic polyurethane (TPU) mats. Overall, NAP-inclusion complex loaded TPU electrospun nanofibres could be used as drug delivery systems for acute pain treatments since they possess a highly porous structure that can release the drug immediately. © AUTEX. en_US
dc.language.iso en en_US
dc.publisher Technical University of Lodz en_US
dc.relation.ispartof Autex Research Journal en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject 2-hydroxy propyl-ß-CD en_US
dc.subject Drug release en_US
dc.subject Electrospinning en_US
dc.subject Inclusion complex en_US
dc.subject Naproxen en_US
dc.subject ß-cyclodextrin en_US
dc.title Electrospun thermoplastic polyurethane mats containing naproxen- cyclodextrin inclusion complex en_US
dc.type Article en_US
dc.identifier.volume 14 en_US
dc.identifier.issue 4 en_US
dc.identifier.startpage 239
dc.identifier.startpage 239 en_US
dc.identifier.endpage 246 en_US
dc.authorid 0000-0002-6379-6697
dc.identifier.doi 10.2478/aut-2014-0024
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.identifier.scopus 2-s2.0-84919768731 en_US
dc.identifier.wos WOS:000346705900004 en_US

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