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Association of the DRD2 TaqIA, 5-HT1B A-161T, and CNR1 1359 G/A polymorphisms with alcohol dependence

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dc.contributor.author Sengul Balci, M.C.
dc.contributor.author Sengul, C.
dc.contributor.author Erdal, M.E.
dc.contributor.author Izci Ay, O.
dc.contributor.author Efe, M.
dc.contributor.author Ay, M.E.
dc.contributor.author Herken, H.
dc.date.accessioned 2019-08-16T12:30:47Z
dc.date.available 2019-08-16T12:30:47Z
dc.date.issued 2014
dc.identifier.issn 10177833 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/7613
dc.description.abstract Objective: Alcohol dependence is associated with genetic variants of alcohol-metabolizing enzymes and genes related to dopaminergic, gamma-aminobutyric acidergic, glutamatergic, opioid, cholinergic, and serotonergic systems. Genetic variations in the endogenous cannabinoid system are also involved in alcohol dependence. The present study aimed to evaluate the association between three polymorphisms, DRD2 TaqIA, 5-HT1B A-161T and CNR1 1359 G/A (rs1049353), and alcohol dependence. Methods: One hundred twenty three patients, who were diagnosed as having alcohol dependence according to the DSM-IV criteria and 125 healthy volunteers, were included in the study. With written informed consent, a blood sample was drawn from each individual. Venous blood samples were collected in ethylenediaminetetra acetic acid (EDTA) containing tubes. DNA was extracted from whole blood by the salting out procedure. Genetic analyses were performed as described in the literature by using a Polymerase Chain Reaction method. SPSS 17.0 software was used for statistical analysis. Results: The DRD2 TaqIA polymorphism was analyzed in the study and control groups. In the study group, the A1/ A1 genotype was observed in 5 (4.0%) patients, the A1/ A2 genotype was observed in 51 (41.5%) patients and the A2/A2 genotype was observed in 67 (54.5%) patients. In the control group, the A1/A1 genotype was observed in 6 (4.8%) subjects, the A1/A2 genotype was observed in 40 (32.0%) subjects and the A2/A2 genotype was observed in 79 (62.2%) subjects. For the 5-HT1B receptor A-161T gene polymorphism, the A/A genotype was detected in 61 (49.6%) patients, the A/T genotype was detected in 53 (43.1%) and the T/T genotype was detected in 9 (7.3%) patients. In the control group, the A/A genotype was detected in 84 (67.2%) subjects, the A/T genotype was detected in 39 (31.2%) subjects, and the T/T genotype was detected only in 2 (1.6%) subjects. The G/G genotype was the most common genotype in both study and control groups for CNR1 1359 gene polymorphism. It was detected in 75 (61.0%) study patients and in 84 (67.2%) control subjects. The G/A genotype was observed in 39 (31.7%) patients of the study group and 38 (30.4%) subjects of the control group. The A/A genotype was the most rare genotype in both groups; it was detected only in 9 (7.3%) study patients and 3 (2.4%) control subjects. Of the three polymorphisms investigated, 5-HT1B A-161T was the only one found to be associated with alcohol dependence. Conclusions: The 5-HT1B receptor A-161T polymorphism might be a promising marker for alcohol dependence; however, future studies are needed to clarify these findings.
dc.language.iso English; Turkish
dc.publisher Cukurova Univ Tip Fakultesi Psikiyatri Anabilim Dali
dc.relation.isversionof 10.5455/bcp.20131229022915
dc.subject 5-HT1B A-161T
dc.subject Alcohol dependence
dc.subject CNR1 1359 G/A
dc.subject DRD2 TaqIA
dc.subject Polymorphism
dc.subject endocannabinoid
dc.subject serotonin 1B receptor
dc.subject adult
dc.subject alcoholism
dc.subject allele
dc.subject article
dc.subject controlled study
dc.subject disease association
dc.subject female
dc.subject genetic analysis
dc.subject genetic association
dc.subject genetic polymorphism
dc.subject genetic variability
dc.subject genotype
dc.subject genotyping technique
dc.subject human
dc.subject major clinical study
dc.subject male
dc.subject real time polymerase chain reaction
dc.subject restriction fragment length polymorphism
dc.subject single nucleotide polymorphism
dc.subject Structured Clinical Interview for DSM Disorders
dc.subject structured questionnaire
dc.title Association of the DRD2 TaqIA, 5-HT1B A-161T, and CNR1 1359 G/A polymorphisms with alcohol dependence
dc.type Article
dc.relation.journal Klinik Psikofarmakoloji Bulteni
dc.identifier.volume 24
dc.identifier.issue 2
dc.identifier.startpage 115
dc.identifier.endpage 121
dc.identifier.index Scopus

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