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Effects of tamoxifen on survival of cutaneous and myocutaneous flap (experimental study)

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dc.contributor.author Özcan, Ramazan Hakan
dc.contributor.author Topkara, Adem
dc.contributor.author Bagdatlı, Dilek
dc.contributor.author Özkan, Adem
dc.contributor.author Aydin, Orhan
dc.contributor.author Çelebi, Tuğrul
dc.date.accessioned 2019-08-16T12:29:38Z
dc.date.available 2019-08-16T12:29:38Z
dc.date.issued 2014
dc.identifier.issn 1128-3602
dc.identifier.uri https://hdl.handle.net/11499/7455
dc.description.abstract OBJECTIVES: Breast cancer is the most common non-skin malignancy in women. In breast cancer, the basic principle of endocrine therapy is to deprive tumor cell from the growth-stimulating effect of estrogens. The oldest, best-known and most widely used endocrine therapy medicine is tamoxifen, which is a selective estrogen receptor blocker. All factors that are known to have adverse effects on flap and pre-reconstruction flap survive should be eliminated 3 weeks before the surgery and started at the end of the 3 rd week after the surgery. When the literature is reviewed, there are limited studies about that tamoxifen increases the risk of deep vein thrombosis and pulmonary embolism. The aim of this study was to research whether tamoxifen had adverse effects on the skin flap and muscle-skin flap survive. MATERIALS AND METHODS: In this study, 32 female Sprague-Davley rats were used. Their weights ranged from 220 to 250 g. 4 groups, each consisting of 8 rats, were formed. In this experimental study, in which rat models were used caudal based rat dorsal skin flap and superior pedicle rectus abdominis musculocutaneous flaps were applied. Control groups were formed for both flap models. Study groups were treated with tamoxifen citrat and control groups were treated with placebo. RESULTS: As a result of the statistical evaluation done by measuring the surviving flap areas, it was found out that tamoxifen had no negative effect on flap survive. CONCLUTIONS: Based on these findings, it was concluded that there was no need to stop tamoxifen as long as 6-7 weeks in patients undergoing breast reconstruction with pedicle flap techniques. en_US
dc.language.iso en en_US
dc.publisher Verduci Editore en_US
dc.relation.ispartof European Review for Medical and Pharmacological Sciences en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Cutaneous flap en_US
dc.subject Flap survival en_US
dc.subject Myocutaneous flap en_US
dc.subject Rat en_US
dc.subject Tamoxifen en_US
dc.subject placebo en_US
dc.subject tamoxifen en_US
dc.subject tamoxifen citrate en_US
dc.subject antineoplastic hormone agonists and antagonists en_US
dc.subject animal experiment en_US
dc.subject animal model en_US
dc.subject article en_US
dc.subject breast cancer en_US
dc.subject breast reconstruction en_US
dc.subject cancer hormone therapy en_US
dc.subject controlled study en_US
dc.subject drug effect en_US
dc.subject female en_US
dc.subject myocutaneous flap en_US
dc.subject nonhuman en_US
dc.subject pedicled skin flap en_US
dc.subject rat en_US
dc.subject rectus abdominis muscle en_US
dc.subject skin flap en_US
dc.subject skin flap survival en_US
dc.subject statistical analysis en_US
dc.subject animal en_US
dc.subject drug effects en_US
dc.subject necrosis en_US
dc.subject pathology en_US
dc.subject skin en_US
dc.subject Sprague Dawley rat en_US
dc.subject surgery en_US
dc.subject surgical flaps en_US
dc.subject time en_US
dc.subject tissue survival en_US
dc.subject Animals en_US
dc.subject Antineoplastic Agents, Hormonal en_US
dc.subject Female en_US
dc.subject Models, Animal en_US
dc.subject Myocutaneous Flap en_US
dc.subject Necrosis en_US
dc.subject Rats, Sprague-Dawley en_US
dc.subject Rectus Abdominis en_US
dc.subject Skin en_US
dc.subject Surgical Flaps en_US
dc.subject Time Factors en_US
dc.subject Tissue Survival en_US
dc.title Effects of tamoxifen on survival of cutaneous and myocutaneous flap (experimental study) en_US
dc.type Article en_US
dc.identifier.volume 18 en_US
dc.identifier.issue 4 en_US
dc.identifier.startpage 493
dc.identifier.startpage 493 en_US
dc.identifier.endpage 499 en_US
dc.authorid 0000-0002-4159-8948
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.identifier.pmid 24610615 en_US
dc.identifier.wos WOS:000341967600008 en_US

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