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Are uremia, diabetes, and atherosclerosis linked with impaired antioxidant mechanisms?

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dc.contributor.author Dursun, B.
dc.contributor.author Dursun, E.
dc.contributor.author Capraz, I.
dc.contributor.author Ozben, T.
dc.contributor.author Apaydin, A.
dc.contributor.author Suleymanlar, G.
dc.date.accessioned 2019-08-16T12:19:53Z
dc.date.available 2019-08-16T12:19:53Z
dc.date.issued 2008
dc.identifier.issn 17088267 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/7325
dc.description.abstract Background: Oxidative stress is a new risk factor for atherosclerosis. Increased oxidative stress in hemodialysis (HD) patients may arise from uremia-associated metabolic/ humoral abnormalities and bioincompatibility of dialysis. Patients with diabetes mellitus (DM) may be subject to an additional risk. Respective influences of uremia, diabetes, and HD duration in accelerated atherosclerosisa nd oxidative stress have not been clarified yet. Methods: The study was performed on 24 nondiabetic HD patients, 23 diabetic HD patients, 20 stages 3 to 4 chronic kidney disease patients, and 21 diabetic patients without overt nephropathy. Carotid intima-media thickness, a surrogate of atherosclerosis, was measured by high-resolution B-mode ultrasonography. Oxidant status was determined by lipid peroxidation as expressed by malondialdehyde (MDA); antioxidant status was determined by superoxide dismutase, catalase, glutathione peroxidase, reduced intracellular glutathione, and plasma thiol. Results: Intima-media thi kness (IMT) was higher in patients undergoing HD but not different between nondiabetic HD patients and diabetic HD patients. No correlation was found between the duration of HD and intima-media thickness. Antioxidants were generally lower in HD patients. Intima-media thickness was positively correlated with MDA and negatively correlated with plasma thiol. Among other risk factors, only age was correlated with intima-media thickness. Conclusions: Increased carotid IMT in HD patients is independent of duration of HD or diabetes status. Age and MDA are the significant predictors of carotid IMT. Increased oxidative stress due to impaired antioxidant mechanisms, particularly reduced plasma thiol redox potential, may account for accelerated atherosclerosis in high-risk patients with chronic kidney failure and/or DM. ©2008 American Federation for Medical Research.
dc.language.iso English
dc.publisher BMJ Publishing Group
dc.relation.isversionof 10.2310/JIM.0b013e3181641ce3
dc.subject Antioxidant mechanisms
dc.subject Atherosclerosis
dc.subject Uremia
dc.subject catalase
dc.subject glutathione
dc.subject glutathione peroxidase
dc.subject superoxide dismutase
dc.subject thiol
dc.subject antioxidant
dc.subject thiol derivative
dc.subject adult
dc.subject antioxidant activity
dc.subject artery intima proliferation
dc.subject article
dc.subject atherosclerosis
dc.subject controlled study
dc.subject diabetes mellitus
dc.subject diabetic patient
dc.subject disease severity
dc.subject echography
dc.subject female
dc.subject human
dc.subject kidney disease
dc.subject lipid peroxidation
dc.subject major clinical study
dc.subject male
dc.subject oxidative stress
dc.subject risk factor
dc.subject uremia
dc.subject carotid artery
dc.subject carotid artery disease
dc.subject diabetic angiopathy
dc.subject diabetic nephropathy
dc.subject metabolism
dc.subject middle aged
dc.subject physiology
dc.subject Antioxidants
dc.subject Carotid Arteries
dc.subject Carotid Artery Diseases
dc.subject Diabetic Angiopathies
dc.subject Diabetic Nephropathies
dc.subject Female
dc.subject Humans
dc.subject Male
dc.subject Middle Aged
dc.subject Oxidative Stress
dc.subject Risk Factors
dc.subject Sulfhydryl Compounds
dc.title Are uremia, diabetes, and atherosclerosis linked with impaired antioxidant mechanisms?
dc.type Article
dc.relation.journal Journal of Investigative Medicine
dc.identifier.volume 56
dc.identifier.issue 2
dc.identifier.startpage 545
dc.identifier.endpage 552
dc.identifier.index Scopus

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