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Disturbance of pro-oxidative/antioxidative balance in allogeneic peripheral blood stem cell transplantation

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dc.contributor.author Sarı, İsmail
dc.contributor.author Cetin, A.
dc.contributor.author Kaynar, L.
dc.contributor.author Saraymen, R.
dc.contributor.author Hacıoğlu, Sibel K.
dc.contributor.author Ozturk, A.
dc.contributor.author Kocyigit, I.
dc.contributor.author Altuntas, F.
dc.contributor.author Eser, B.
dc.date.accessioned 2019-08-16T12:18:04Z
dc.date.available 2019-08-16T12:18:04Z
dc.date.issued 2008
dc.identifier.issn 00917370 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/7218
dc.description.abstract High dose chemotherapy causes increased free radical formation and depletion of tissue antioxidants. Whether allogeneic hematopoietic stem cell transplantation (HSCT) has an effect on oxidative stress is uncertain. The aims of the study were to determine the effect of allogeneic HSCT on plasma concentrations of antioxidants and oxidative stress biomarkers, and to investigate their relationships with graft-versus-host disease (GVHD), conditioning regimens, and transplant-related mortality (TRM) in patients with hematological malignancies. Patients (n=25) undergoing allogeneic HSCT from HLA-matched sibling donors were enrolled in the study. Plasma oxidant and antioxidant status were measured at day -1 before transplantation and 30 days after HSCT. In both myeloablative (n=14) and non-myeloablative (n=11) transplant groups, the mean levels of plasma malondialdehyde (MDA) and nitric oxide (NO) increased after allogeneic HSCT (p <0.01), whereas superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) activities decreased compared with baseline values (p <0.01). No significant relationships were found between either the pretransplant or post-transplant mean levels of the oxidative stress parameters and the existence of graft-versus-host disease (GVHD), the type of conditioning regimen, or transplant related mortality (TRM). This study documents a significant disturbance of pro-oxidative/antioxidative balance in the plasma of patients undergoing allogeneic HSCT regardless of the intensity of the conditioning regimen. © 2008 by the Association of Clinical Scientists, Inc.
dc.language.iso English
dc.rights info:eu-repo/semantics/closedAccess
dc.subject Allogeneic stem cell transplantation
dc.subject Free radicals
dc.subject Oxidative stress
dc.subject antioxidant
dc.subject busulfan
dc.subject catalase
dc.subject cyclophosphamide
dc.subject fludarabine
dc.subject free radical
dc.subject glutathione peroxidase
dc.subject malonaldehyde
dc.subject nitric oxide
dc.subject superoxide dismutase
dc.subject acute granulocytic leukemia
dc.subject acute lymphoblastic leukemia
dc.subject adult
dc.subject allogeneic peripheral blood stem cell transplantation
dc.subject antioxidant activity
dc.subject article
dc.subject blood level
dc.subject chronic myeloid leukemia
dc.subject clinical article
dc.subject female
dc.subject graft versus host reaction
dc.subject hematologic malignancy
dc.subject human
dc.subject human tissue
dc.subject male
dc.subject mortality
dc.subject multiple cycle treatment
dc.subject myeloablative conditioning
dc.subject myelofibrosis
dc.subject nonhodgkin lymphoma
dc.subject nonmyeloablative conditioning
dc.subject oxidative stress
dc.subject priority journal
dc.subject statistical analysis
dc.subject Adult
dc.subject Antioxidants
dc.subject Biological Markers
dc.subject Catalase
dc.subject Female
dc.subject Glutathione Peroxidase
dc.subject Graft vs Host Disease
dc.subject Humans
dc.subject Male
dc.subject Malondialdehyde
dc.subject Middle Aged
dc.subject Nitric Oxide
dc.subject Oxidants
dc.subject Oxidative Stress
dc.subject Peripheral Blood Stem Cell Transplantation
dc.subject Superoxide Dismutase
dc.subject Transplantation Conditioning
dc.subject Transplantation, Homologous
dc.title Disturbance of pro-oxidative/antioxidative balance in allogeneic peripheral blood stem cell transplantation
dc.type Article
dc.relation.journal Annals of Clinical and Laboratory Science
dc.contributor.authorID 0000-0003-0757-9206
dc.identifier.volume 38
dc.identifier.issue 2
dc.identifier.startpage 120
dc.identifier.endpage 125
dc.relation.publicationCategory Uluslararası Hakemli Dergi
dc.identifier.index Scopus
dc.identifier.index WOS
dc.identifier.index PubMed

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