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Phaeochromocytoma combined with subclinical Cushing's syndrome and pituitary microadenoma

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dc.contributor.author Yaylali, G.F.
dc.contributor.author Akin, F.
dc.contributor.author Bastemir, M.
dc.contributor.author Yaylali, Y.T.
dc.contributor.author Ozden, A.
dc.date.accessioned 2019-08-16T12:16:20Z
dc.date.available 2019-08-16T12:16:20Z
dc.date.issued 2008
dc.identifier.issn 0147958X (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/7136
dc.description.abstract Objectives: Phaeochromocytoma (PHEO) occasionally associates with pathological lesions of the adrenal cortex. The coexistence of PHEO and pre-clinical Cushing's syndrome (PCS) of the same adrenal gland has rarely been reported. We report a case of PHEO and PCS originating from the same adrenal gland and discuss the peculiar diagnostic aspects of this entity. Clinical Presentation: A 64 yr old man was hospitalized to evaluate the right adrenal mass which was discovered incidentally by ultrasonography. He had a history of type 2 diabetes mellitus and hyperlipidemia. Blood pressure measurements were all normal during his hospital stay. Laboratory examination showed: urinary catecholamines were markedly increased. HbA1C of 14.3 %, midnight cortisol of 11(μg/dL), cortisol was not suppressed after the overnight 1 mg oral dexamethasone suppression test (DST): 3.42(μg/dL), 24 hr free cortisol in the urine : 213 g/day (10-100), cortisol levels were suppressed more than 50% with 8 mg of dexamethasone. CT scan of the adrenal glands showed a 6 cm well encapsulated right adrenal mass together with a clearly normal left adrenal gland. MRI investigation of the sella turcica revealed a pituitary microadenoma on the right side of the adenohypophysis He was treated with α and subsequent β blockers after the diagnosis of PHEO and PCS was made. Right adrenalectomy was performed. The pathology showed typical PHEO with adrenocortical hyperplasia. VMA, metanefrin and free cortisol levels were normalized one month after surgery. Conclusion: The present report is a rare case of PHEO combined with PCS in the same adrenal gland. © 2008 CIM.
dc.language.iso English
dc.subject alpha adrenergic receptor blocking agent
dc.subject beta adrenergic receptor blocking agent
dc.subject carvedilol
dc.subject doxazosin
dc.subject hemoglobin A1c
dc.subject insulin
dc.subject metformin
dc.subject methylprednisolone
dc.subject repaglinide
dc.subject rosiglitazone
dc.subject vitamin D
dc.subject dexamethasone
dc.subject diagnostic agent
dc.subject hydrocortisone
dc.subject adrenal tumor
dc.subject adrenalectomy
dc.subject adult
dc.subject article
dc.subject case report
dc.subject catecholamine urine level
dc.subject clinical feature
dc.subject comorbidity
dc.subject Cushing syndrome
dc.subject dexamethasone suppression test
dc.subject drug dose reduction
dc.subject drug withdrawal
dc.subject echography
dc.subject histopathology
dc.subject human
dc.subject hyperlipidemia
dc.subject hypophysis adenoma
dc.subject male
dc.subject non insulin dependent diabetes mellitus
dc.subject nuclear magnetic resonance imaging
dc.subject osteomalacia
dc.subject pheochromocytoma
dc.subject priority journal
dc.subject adenoma
dc.subject blood
dc.subject drug antagonism
dc.subject hypophysis tumor
dc.subject middle aged
dc.subject Adenoma
dc.subject Adrenal Gland Neoplasms
dc.subject Cushing Syndrome
dc.subject Dexamethasone
dc.subject Diabetes Mellitus, Type 2
dc.subject Humans
dc.subject Hydrocortisone
dc.subject Hyperlipidemias
dc.subject Male
dc.subject Middle Aged
dc.subject Pheochromocytoma
dc.subject Pituitary Neoplasms
dc.title Phaeochromocytoma combined with subclinical Cushing's syndrome and pituitary microadenoma
dc.type Article
dc.relation.journal Clinical and Investigative Medicine
dc.identifier.volume 31
dc.identifier.issue 3
dc.identifier.startpage E176
dc.identifier.endpage E181
dc.identifier.index Scopus

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