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The effects of diabetes mellitus, age, and vitamin E on testicular oxidative stress

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dc.contributor.author Aybek, Hülya
dc.contributor.author Aybek, Zafer
dc.contributor.author Rota, S.
dc.contributor.author Şen, Nilay
dc.contributor.author Akbulut, M.
dc.date.accessioned 2019-08-16T12:15:02Z
dc.date.available 2019-08-16T12:15:02Z
dc.date.issued 2008
dc.identifier.issn 0015-0282
dc.identifier.uri https://hdl.handle.net/11499/7061
dc.identifier.uri https://doi.org/10.1016/j.fertnstert.2007.01.101
dc.description.abstract Objective: To examine the effects of age and/or diabetes on oxidative stress and steroidogenesis, and the protective effect of vitamin E in testis tissue. Design: Controlled experimental study. Setting: Pamukkale University School of Medicine animal facility. Animal(s): Male Wistar rats divided into six groups with six animals in each group: young control; young diabetic; young diabetic with vitamin E treatment; aged control; aged diabetic; and aged diabetic with vitamin E treatment. Intervention(s): Diabetes was induced by a single intraperitoneal injection of 50 mg/kg streptozotocin and was confirmed by testing blood glucose levels 5 to 7 days after injection. Vitamin E was administered orally for 6 weeks. Main Outcome Measure(s): Serum testosterone and tissue malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH) levels were measured, and testis tissue was examined histopathologically. Result(s): Elevated malondialdehyde and reduced superoxide dismutase, glutathione, and serum testosterone levels were detected only in the young and aged-diabetic groups. Histopathologic change was not detected in the testis tissue in any of the groups. Conclusion(s): Age does not alter the effects of diabetes-induced free radical damage in testis tissue; improvement in this damage can be achieved by vitamin E treatment. © 2008 American Society for Reproductive Medicine. en_US
dc.language.iso en en_US
dc.relation.ispartof Fertility and Sterility en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject age en_US
dc.subject Diabetes mellitus en_US
dc.subject reactive oxygen species en_US
dc.subject testosterone en_US
dc.subject vitamin E en_US
dc.subject alpha tocopherol en_US
dc.subject glucose en_US
dc.subject glutathione en_US
dc.subject malonaldehyde en_US
dc.subject streptozocin en_US
dc.subject superoxide dismutase en_US
dc.subject aging en_US
dc.subject animal experiment en_US
dc.subject animal model en_US
dc.subject animal tissue en_US
dc.subject article en_US
dc.subject controlled study en_US
dc.subject diabetes mellitus en_US
dc.subject glucose blood level en_US
dc.subject histopathology en_US
dc.subject male en_US
dc.subject nonhuman en_US
dc.subject oxidative stress en_US
dc.subject priority journal en_US
dc.subject rat en_US
dc.subject steroidogenesis en_US
dc.subject testis function en_US
dc.subject vitamin supplementation en_US
dc.subject Aging en_US
dc.subject Animals en_US
dc.subject Diabetes Mellitus en_US
dc.subject Male en_US
dc.subject Oxidative Stress en_US
dc.subject Rats en_US
dc.subject Reactive Oxygen Species en_US
dc.subject Streptozocin en_US
dc.subject Testis en_US
dc.subject Vitamin E en_US
dc.title The effects of diabetes mellitus, age, and vitamin E on testicular oxidative stress en_US
dc.type Article en_US
dc.identifier.volume 90 en_US
dc.identifier.issue 3 en_US
dc.identifier.startpage 755
dc.identifier.startpage 755 en_US
dc.identifier.endpage 760 en_US
dc.authorid 0000-0002-0635-4251
dc.authorid 0000-0002-8294-558X
dc.identifier.doi 10.1016/j.fertnstert.2007.01.101
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.identifier.pmid 17482598 en_US
dc.identifier.scopus 2-s2.0-51449110884 en_US
dc.identifier.wos WOS:000259317200039 en_US

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