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High ceruloplasmin levels are associated with obsessive compulsive disorder: A case control study

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dc.contributor.author Virit, O.
dc.contributor.author Selek, S.
dc.contributor.author Bulut, M.
dc.contributor.author Savas, H.A.
dc.contributor.author Celik, H.
dc.contributor.author Erel, O.
dc.contributor.author Herken, Hasan
dc.date.accessioned 2019-08-16T12:14:17Z
dc.date.available 2019-08-16T12:14:17Z
dc.date.issued 2008
dc.identifier.issn 1744-9081
dc.identifier.uri https://hdl.handle.net/11499/7015
dc.identifier.uri https://doi.org/10.1186/1744-9081-4-52
dc.description.abstract Background: Alterations in ceruloplasmin are currently assumed as one of the mechanisms underlying the development of a number of neurodegenerative disorders. Several studies indicate that elevated serum ceruloplasmin levels may play a role in schizophrenia by exacerbating or perpetuating dopaminergic dysregulation. No study investigating the relationship between ceruloplasmin and obsessive-compulsive disorder (OCD) has been published to date. Nowadays OCD is increasingly speculated to be a different disorder than other anxiety disorders, and rather is considered to be more similar to psychotic disorders. The objective of this study to explore whether there is an association of ceruloplasmin with OCD as in schizophrenia. Method: 26 pure OCD and 9 co-morbid OCD patients from Gaziantep University Sahinbey Research Hospital, Psychiatry Clinics, diagnosed according to the DSM IV and 40 healthy controls were included in the study. Blood samples were collected; ceruloplasmin levels were measured. Results: The mean ceruloplasmin level in pure OCD patients, co-morbid OCD patients, and control group persons were 544.46 ± 26.53, 424.43 ± 31.50 and 222.35 ± 8.88 U/L respectively. Results of all 3 groups differ significantly. Positive predictive value of ceruloplasmin for that cut-off point is 31/31 (100%) and negative predictive value is 40/44 (91%) in our group. Conclusion: Although the nature of relationship is not clear there was an association between ceruloplasmin levels and OCD in our study. © 2008 Virit et al; licensee BioMed Central Ltd. en_US
dc.language.iso en en_US
dc.relation.ispartof Behavioral and Brain Functions en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject ceruloplasmin en_US
dc.subject adult en_US
dc.subject article en_US
dc.subject blood sampling en_US
dc.subject case control study en_US
dc.subject clinical article en_US
dc.subject colorimetry en_US
dc.subject controlled study en_US
dc.subject diagnostic accuracy en_US
dc.subject diagnostic and statistical manual of mental disorders en_US
dc.subject disease severity en_US
dc.subject female en_US
dc.subject genetic association en_US
dc.subject human en_US
dc.subject male en_US
dc.subject obsessive compulsive disorder en_US
dc.subject priority journal en_US
dc.subject protein blood level en_US
dc.subject sensitivity and specificity en_US
dc.title High ceruloplasmin levels are associated with obsessive compulsive disorder: A case control study en_US
dc.type Article en_US
dc.identifier.volume 4 en_US
dc.identifier.doi 10.1186/1744-9081-4-52
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.identifier.pmid 19017404 en_US
dc.identifier.scopus 2-s2.0-57649235189 en_US
dc.identifier.wos WOS:000261508500001 en_US

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