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The expression of novel gene URG4 in osteosarcoma: Correlation with patients' prognosis

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dc.contributor.author Huang, J.
dc.contributor.author Zhu, B.
dc.contributor.author Lu, L.
dc.contributor.author Lian, Z.
dc.contributor.author Wang, Y.
dc.contributor.author Yang, X.
dc.contributor.author Satiroglu-Tufan, N.L.
dc.contributor.author Liu, J.
dc.contributor.author Luo, Z.
dc.date.accessioned 2019-08-16T12:13:24Z
dc.date.available 2019-08-16T12:13:24Z
dc.date.issued 2009
dc.identifier.issn 00313025 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/6949
dc.description.abstract Aims: Up-regulated gene 4 (URG4) is a novel gene that may be associated with the onset of tumorigenesis and cell cycle regulation. The present study examined for the first time the expression of URG4 in osteosarcoma, which is one of the most rapidly growing sarcomas, and investigated its prognostic value in both disease-free and overall survival of the patients. Methods: The expression of URG4 in osteosarcoma tissues was examined by immunohistochemistry in 46 patients who underwent surgical operation for osteosarcoma; the correlation of URG4 with proliferating cell nuclear antigen index (PCNA) and microvessel count (MVC) was analysed, and the prognostic value of URG4 in patients was investigated. Results: URG4 was highly expressed in 40 of 46 (86.96%) osteosarcoma specimens with cytoplasmic staining, and also increased in the specimens with recurrence (p < 0.05) and metastasis (p < 0.05). The mean disease-free survival and overall survival were 50.25 and 54.08 months for patients with over-expressed URG4, compared with 69.54 and 70.01 months for those with low expression. URG4 was also found to be highly related with PCNA, while no significant relationship was found between URG4 and MVC. Conclusions: URG4 may play important roles in the development of osteosarcoma, and might be a useful molecular marker for predicting the prognosis of osteosarcoma. © 2009 Royal College of Pathologists of Australasia.
dc.language.iso English
dc.publisher Taylor and Francis Ltd.
dc.relation.isversionof 10.1080/00313020802436808
dc.subject MVC
dc.subject Osteosarcoma
dc.subject PCNA
dc.subject Prognosis
dc.subject URG4
dc.subject cycline
dc.subject adult
dc.subject article
dc.subject cancer recurrence
dc.subject clinical article
dc.subject controlled study
dc.subject correlation analysis
dc.subject disease free survival
dc.subject female
dc.subject gene expression
dc.subject human
dc.subject human tissue
dc.subject immunohistochemistry
dc.subject male
dc.subject nucleotide sequence
dc.subject osteosarcoma
dc.subject overall survival
dc.subject prognosis
dc.subject statistical significance
dc.subject tumor gene
dc.subject up regulated gene 4
dc.title The expression of novel gene URG4 in osteosarcoma: Correlation with patients' prognosis
dc.type Article
dc.relation.journal Pathology
dc.identifier.volume 41
dc.identifier.issue 2
dc.identifier.startpage 149
dc.identifier.endpage 154
dc.identifier.index Scopus


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