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Chorangiosis: The potential role of smoking and air pollution

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dc.contributor.author Akbulut, M.
dc.contributor.author Sorkun, H.C.
dc.contributor.author Bir, F.
dc.contributor.author Eralp, A.
dc.contributor.author Duzcan, E.
dc.date.accessioned 2019-08-16T12:12:13Z
dc.date.available 2019-08-16T12:12:13Z
dc.date.issued 2009
dc.identifier.issn 03440338 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/6873
dc.description.abstract Chorangiosis is considered to be strongly associated with various fetal, maternal, and placental disorders, including pre-eclampsia, diabetes, hypertension, and major congenital anomalies, and has been found to correlate with increased fetal morbidity and mortality. In this study, we investigated the pathologic effects of maternal smoking and air pollution on the pathogenesis of chorangiosis. We investigated 92 placentas macroscopically and microscopically over a 3-month period (March 2006-May 2006) at Denizli State Hospital to identify the frequency of chorangiosis and the potential role of maternal smoking and air pollution. Placental changes were examined by light microscopy after hematoxylin and eosin (H&E) staining and immunohistochemical evaluation of CD 34 and CD 68; muscle-specific actin was used to confirm the diagnosis. Among the 92 mothers included in the study, 33 were smokers (group I), 31 were thought to have been exposed to air pollution (group II), and 28 were living in rural areas free of air pollution and maternal smoking (group III). Chorangiosis was found in 14% (13/92) of all placentas: 7 (53.8%) cases were assigned to group I, 5 (38.5%) to group II, and 1 (7.7%) to group III. Vascular changes were found mainly in the smoking and air pollution groups. There appeared to be no correlation of these vascular changes with placental weight, parity, gestational age, major congenital anomalies, and maternal factors, including diabetes and pre-eclampsia. We presume that smoking and air pollution may contribute to the development of chorangiosis. We suggest that chorangiosis may be an adaptive response to maternal hypoxia, and studies addressing the role of smoking and air pollution in chorangiosis may provide new insights into the pathogenesis of this condition. © 2008 Elsevier GmbH. All rights reserved.
dc.language.iso English
dc.relation.isversionof 10.1016/j.prp.2008.05.004
dc.subject Air pollution
dc.subject Chorangiosis
dc.subject Maternal hypoxia
dc.subject Smoking
dc.subject actin
dc.subject CD34 antigen
dc.subject CD68 antigen
dc.subject adult
dc.subject air pollution
dc.subject article
dc.subject chorangiosis
dc.subject controlled study
dc.subject disease association
dc.subject environmental exposure
dc.subject female
dc.subject histopathology
dc.subject human
dc.subject human tissue
dc.subject immunohistochemistry
dc.subject major clinical study
dc.subject maternal smoking
dc.subject microscopy
dc.subject placenta circulation
dc.subject placenta disorder
dc.subject risk assessment
dc.subject risk factor
dc.subject vascular disease
dc.subject Adult
dc.subject Air Pollution
dc.subject Chorionic Villi
dc.subject Female
dc.subject Humans
dc.subject Maternal Exposure
dc.subject Placenta Diseases
dc.subject Pregnancy
dc.subject Pregnancy Complications
dc.title Chorangiosis: The potential role of smoking and air pollution
dc.type Article
dc.relation.journal Pathology Research and Practice
dc.identifier.volume 205
dc.identifier.issue 2
dc.identifier.startpage 75
dc.identifier.endpage 81
dc.identifier.index Scopus

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