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Oxidative mechanisms in schizophrenia and their relationship with illness subtype and symptom profile

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dc.contributor.author Pazvantoglu, O.
dc.contributor.author Selek, S.
dc.contributor.author Okay, I.T.
dc.contributor.author Şengül, Cem.
dc.contributor.author Karabekiroglu, K.
dc.contributor.author Dilbaz, N.
dc.contributor.author Erel, O.
dc.date.accessioned 2019-08-16T12:09:36Z
dc.date.available 2019-08-16T12:09:36Z
dc.date.issued 2009
dc.identifier.issn 1323-1316
dc.identifier.uri https://hdl.handle.net/11499/6681
dc.identifier.uri https://doi.org/10.1111/j.1440-1819.2009.02015.x
dc.description.abstract Aim: The aim of the present study was to investigate the differences in the antioxidant-oxidant balance (AO-OB) between schizophrenic patients and healthy individuals and to explore the relationship of AO-OB with illness subtypes and symptom profiles. Methods: After a 15-day drug-free period, schizophrenia patients (n = 50) in a clinical sample, and age- and sex-matched healthy subjects (n = 49) were enrolled. Total antioxidant potentials (TAOP) and total peroxide levels (TPEROX) of all participants were measured and the oxidative stress index (OSI) was calculated. The assessment included structured measurements, including the Positive and Negative Syndrome Scale (PANSS), and the Brief Psychiatric Rating Scale (BPRS). Results: TAOP had a significant positive correlation with age at onset of schizophrenia (P = 0.013), a negative correlation with the PANSS negative subscale scores (P = 0.008), a negative correlation with the PANSS total scores (P < 0.001), and a significant negative correlation with BPRS scores (P = 0.001). OSI had a significant negative correlation with age at onset (P = 0.046) and a significant positive correlation with PANSS negative subscale (P = 0.015). A multiple regression model indicated a significant linear combination of age, gender, duration of illness, subtype of schizophrenia, and PANSS scores, in which only the subtype of schizophrenia made a statistically significant contribution to predicting mean OSI (F[5,35] = 2.44, P = 0.04). Conclusion: Several parameters in the pathogenesis of schizophrenia, such as age of onset, level of negative symptoms, and subtype of illness, but not the presence of the illness itself, are associated with the level of oxidative stress. © 2009 Japanese Society of Psychiatry and Neurology. en_US
dc.language.iso en en_US
dc.relation.ispartof Psychiatry and Clinical Neurosciences en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Oxidative stress en_US
dc.subject PANSS en_US
dc.subject Schizophrenia en_US
dc.subject Subtype en_US
dc.subject Total antioxidant potential en_US
dc.subject peroxide en_US
dc.subject adult en_US
dc.subject article en_US
dc.subject Brief Psychiatric Rating Scale en_US
dc.subject clinical article en_US
dc.subject controlled study en_US
dc.subject disease duration en_US
dc.subject female en_US
dc.subject human en_US
dc.subject male en_US
dc.subject onset age en_US
dc.subject oxidative stress en_US
dc.subject Positive and Negative Syndrome Scale en_US
dc.subject schizophrenia en_US
dc.subject Adult en_US
dc.subject Age of Onset en_US
dc.subject Antioxidants en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Oxidative Stress en_US
dc.subject Peroxides en_US
dc.subject Psychiatric Status Rating Scales en_US
dc.subject Severity of Illness Index en_US
dc.title Oxidative mechanisms in schizophrenia and their relationship with illness subtype and symptom profile en_US
dc.type Article en_US
dc.identifier.volume 63 en_US
dc.identifier.issue 5 en_US
dc.identifier.startpage 693
dc.identifier.startpage 693 en_US
dc.identifier.endpage 700 en_US
dc.authorid 0000-0003-4067-6040
dc.identifier.doi 10.1111/j.1440-1819.2009.02015.x
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.identifier.pmid 19788631 en_US
dc.identifier.scopus 2-s2.0-70349303526 en_US
dc.identifier.wos WOS:000270153200013 en_US

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