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IGF-1 gene polymorphism in obese patients with insulin resistance

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dc.contributor.author Fidan Yaylali, G.
dc.contributor.author Akin, F.
dc.contributor.author Turgut, S.
dc.contributor.author Kursunluoglu, R.
dc.date.accessioned 2019-08-16T12:08:10Z
dc.date.available 2019-08-16T12:08:10Z
dc.date.issued 2010
dc.identifier.issn 03014851 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/6518
dc.description.abstract IGFs (Insulin like growth factors) are important regulators of pancreatic β cell development, growth and maintenance. Mutations in the IGF genes have been found to be associated with diabetes mellitus, myocardial infarction obesity. These associations could result from changes in insulin secretion. We aimed to investigate IGF-1 gene polymorphism in obese patients with insulin resistance. We included 100 obese patients with insulin resistance 30 healthy subjects to study. At baseline examinations, antropometric measurements were done. Genomic DNA from the patients and controls were prepared. Thyroid function tests and serum IGFBP3 levels were similar between patients and controls whereas IGF, GH levels were significantly lower in obese patients. We categorized the IGF-1 (CA)19 polymorphism area into 3 groups as lower than 192 bp (group 1), 192-194 bp (group 2), and higher than 194 bp(group 3). Group 3 was more frequent in both obese and control groups. IGF-1 levels were also significantly lower in obese group (138.51 ± 49.3) in than controls (218.14 ± 69.15). IGF-1 levels were significantly lower in obese patients. The most frequent IGF-1 gen polymorphism allel is >194 bp in both obese insulin resistant patients and controls. IGF-1 levels and the other biochemical and hormonal parameters were similar in different genotype groups. The cause of lower IGF-1 levels in obese patients might be different from IGF-1 gene polymorphism and it may be insulin resistance. © 2009 Springer Science+Business Media B.V.
dc.language.iso English
dc.relation.isversionof 10.1007/s11033-009-9729-6
dc.subject IGF-1 gene polymorphisim
dc.subject Insulin resistance
dc.subject Obesity
dc.subject genomic DNA
dc.subject growth hormone
dc.subject insulin
dc.subject somatomedin binding protein 3
dc.subject somatomedin C
dc.subject adult
dc.subject anthropometry
dc.subject article
dc.subject controlled study
dc.subject DNA polymorphism
dc.subject female
dc.subject genotype
dc.subject human
dc.subject insulin resistance
dc.subject major clinical study
dc.subject male
dc.subject obesity
dc.subject protein blood level
dc.subject thyroid function test
dc.subject Adult
dc.subject Body Mass Index
dc.subject Body Weight
dc.subject Case-Control Studies
dc.subject Female
dc.subject Hormones
dc.subject Humans
dc.subject Insulin Resistance
dc.subject Insulin-Like Growth Factor I
dc.subject Male
dc.subject Polymorphism, Genetic
dc.title IGF-1 gene polymorphism in obese patients with insulin resistance
dc.type Article
dc.relation.journal Molecular Biology Reports
dc.identifier.volume 37
dc.identifier.issue 1
dc.identifier.startpage 529
dc.identifier.endpage 533
dc.identifier.index Scopus


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