DSpace Repository

The effects of in vivo and ex vivo various degrees of cold exposure on erythrocyte deformability and aggregation

Show simple item record

dc.contributor.author Erken, G.
dc.contributor.author Erken, H.A.
dc.contributor.author Bor-Kucukatay, M.
dc.contributor.author Kucukatay, V.
dc.contributor.author Genc, O.
dc.date.accessioned 2019-08-16T12:04:20Z
dc.date.available 2019-08-16T12:04:20Z
dc.date.issued 2011
dc.identifier.issn 12341010 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/6118
dc.description.abstract Background: This study aimed to investigate alterations in hemorheology by cold exposure, in vivo and ex vivo, and to determine their relationship to oxidative stress. Material/Methods: Rats were divided into 2 in vivo and ex vivo cold exposure groups. The in vivo group was further divided into control (AR), AC (4°C, 2 hours) and ALTC (4°C, 6 hours) subgroups; and the ex vivo group was divided into control (BR) and BC (4°C, 2 hours) subgroups. Blood samples were used for the determination of erythrocyte deformability, aggregation, and oxidative stress parameters. Results: Erythrocyte deformability and aggregation were not affected by 2-hour ex vivo cold exposure. While 2 hour in vivo cold exposure reduced erythrocyte deformability, it returned to normal after 6 hours, possibly due the compensation by acute neuroendocrine response. Six hours of cold exposure decreased aggregation index, and might be an adaptive mechanism allowing the continuation of circulation. Aggregation of ex vivo groups was lower compared to in vivo groups. Cold exposure at various temperatures did not cause alterations in plasma total oxidant antioxidant status and oxidative stress index (TOS, TAS, OSI) when considered together. Conclusions: Results of this study indicate that the alterations observed in hemorheological parameters due to cold exposure are far from being explained by the oxidative stress parameters determined herein. © Med Sci Monit.
dc.language.iso English
dc.publisher International Scientific Literature Inc.
dc.relation.isversionof 10.12659/MSM.881899
dc.subject Aggregation
dc.subject Cold
dc.subject Deformability
dc.subject Rat
dc.subject Red blood cell
dc.subject animal cell
dc.subject animal experiment
dc.subject article
dc.subject cold exposure
dc.subject controlled study
dc.subject erythrocyte aggregation
dc.subject erythrocyte deformability
dc.subject ex vivo study
dc.subject in vivo study
dc.subject neuroendocrine system
dc.subject nonhuman
dc.subject oxidative stress
dc.title The effects of in vivo and ex vivo various degrees of cold exposure on erythrocyte deformability and aggregation
dc.type Article
dc.relation.journal Medical Science Monitor
dc.identifier.volume 17
dc.identifier.issue 8
dc.identifier.startpage BR209
dc.identifier.endpage BR215
dc.identifier.index Scopus

Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record