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Generalized bullous fixed drug eruption associated with cetirizine and hydroxyzine demonstrated by patch test

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dc.contributor.author Arslan, Şafak
dc.contributor.author Taşlı, Levent
dc.contributor.author Kaçar, Nida
dc.contributor.author Ergin, Şeniz
dc.date.accessioned 2019-08-16T12:03:50Z
dc.date.available 2019-08-16T12:03:50Z
dc.date.issued 2011
dc.identifier.issn 1019-214X
dc.identifier.uri https://hdl.handle.net/11499/6035
dc.identifier.uri https://doi.org/10.4274/turkderm.45.12
dc.description.abstract Fixed drug eruption (FDE) is characterized by solitary erythematous macules, edematous plaques and bullous lesions that occur at the same place with recurrent exposure to a drug. Though more than 100 drugs have been implicated in leading to FDE, this side effect is more commonly caused by tetracyclines, sulfonamides, sulfone, penicillins, pyrazolones, barbiturates, phenolphthalein, pirazones, aspirin, oral contraceptives and nonsteroidal anti-inflammatory drugs. FDE occurrence has been reported in association with cetrizine, hydroxyzine, loratadine and levocetirizine, which are widely used in the treatment of allergic diseases, such as allergic rhinitis, eczema, asthma, urticaria. Patch, intradermal skin, prick tests or oral challenge test can be performed to identify the agent responsible for FDE. A 43-year-old male patient attended our outpatient clinic with itchy and erythematous rashes with sporadic blisters, starting from dorsum of his feet and spreading to other parts of his body, following oral intake of cetirizine for allergic rhinitis. He described that his eruptions exacerbated with hydoxyzin. Patient's history revealed that he had slightly suffered from the same cutaneous reactions one year ago, after oral administration of cetirizine. On physical examination, multiple, round, erythematoviolaceous, well-defined macules and plaques, with central blisters localized on the trunk, arms and legs were observed. Four months after the lesions regressed, patch test was performed to eight different antihistamines. The test was positive for cetirizine, levocetirizine and hydroxyzine. en_US
dc.language.iso tr en_US
dc.relation.ispartof Turkderm Deri Hastaliklari ve Frengi Arsivi en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Cetirizine en_US
dc.subject Fixed drug eruption en_US
dc.subject Hydroxyzine en_US
dc.subject Levocetirizine en_US
dc.subject antihistaminic agent en_US
dc.subject cetirizine en_US
dc.subject hydroxyzine en_US
dc.subject levocetirizine en_US
dc.subject adult en_US
dc.subject allergic rhinitis en_US
dc.subject article en_US
dc.subject blister en_US
dc.subject bullous skin disease en_US
dc.subject case report en_US
dc.subject drug eruption en_US
dc.subject erythema en_US
dc.subject human en_US
dc.subject male en_US
dc.subject patch test en_US
dc.subject rash en_US
dc.title Generalized bullous fixed drug eruption associated with cetirizine and hydroxyzine demonstrated by patch test en_US
dc.title.alternative Deri yama testiyle doğrulanmış setirizin ve hidroksizin ile ilişkili generalize büllöz fiks ilaç erüpsiyonu en_US
dc.type Article en_US
dc.identifier.volume 45 en_US
dc.identifier.issue 1 en_US
dc.identifier.startpage 49
dc.identifier.startpage 49 en_US
dc.identifier.endpage 52 en_US
dc.identifier.doi 10.4274/turkderm.45.12
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.identifier.scopus 2-s2.0-79953716830 en_US
dc.identifier.wos WOS:000290462900012 en_US

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