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Effect of adding diltiazem to cold blood potassium cardioplegia on myocardial protection

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dc.contributor.author Baltalarli, A.
dc.contributor.author Turkoz, R.
dc.contributor.author Sirin, B.H.
dc.contributor.author Yilik, L.
dc.contributor.author Ozbek, C.
dc.contributor.author Akcay, A.
dc.contributor.author Dengiz, B.
dc.contributor.author Sagban, M.
dc.date.accessioned 2019-08-16T11:52:52Z
dc.date.available 2019-08-16T11:52:52Z
dc.date.issued 1996
dc.identifier.issn 10165169 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/5718
dc.description.abstract It is still controversial whether the use of calcium channel blockers in cardioplegic solutions decreases ischemic and reperfusion damage. In this study, the effect of diltiazem addition to cold blood potassium cardioplegia in the induction phase on myocardial protection was investigated. A prospective, randomized trial was instituted to evaluate the hemodynamic and myocardial metabolic recovery in 20 patients undergoing elective aortocoronary bypass with either diltiazem in cold blood potassium cardioplegia (diltiazem group, n=10) or cold blood potassium cardioplegia (control group, n=10). In the diltiazem group, 150 mg/kg diltiazem was added to the cardioplegic solution in the induction phase of cardioplegia. In all cases, blood samples for measurement of lactate level and calculation of lactate extraction were taken from coronary sinus and radial artery at the beginning and the 30th minute of reperfusion period. CK-MB levels were measured in the intensive care at postoperative 6th and 18th hours. The hemodynamic findings of both diltiazem and control groups were compared in the preoperative and early postoperative periods. Lactate production was significantly lower in the diltiazem group at the beginning of the reperfusion period (p<0.01). Calculated lactate extractions were similar in the two groups at the 30th minute of reperfusion (p>0.05). CK-MB level was significantly higher in the control group in the postoperative period. Similar hemodynamic findings were obtained in both groups in the preoperative and the early postoperative periods. We concluded that diltiazem addition to cold blood potassium cardioplegia decreases ischemic and reperfusion damage and has a beneficial effect on myocardial protection.
dc.language.iso Turkish
dc.subject cardioplegic agent
dc.subject diltiazem
dc.subject lactic acid
dc.subject article
dc.subject cardioplegia
dc.subject clinical article
dc.subject clinical trial
dc.subject controlled clinical trial
dc.subject controlled study
dc.subject heart muscle ischemia
dc.subject heart protection
dc.subject hemodynamics
dc.subject human
dc.subject randomized controlled trial
dc.subject reperfusion injury
dc.title Effect of adding diltiazem to cold blood potassium cardioplegia on myocardial protection
dc.type Article
dc.relation.journal Turk Kardiyoloji Dernegi Arsivi
dc.identifier.volume 24
dc.identifier.issue 2
dc.identifier.startpage 102
dc.identifier.endpage 106+70
dc.identifier.index Scopus

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