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The effects of calcium channel blocker, flunarizine on spinal reflexes in the cats.

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dc.contributor.author Genç, O.
dc.contributor.author Demir, S.
dc.contributor.author Tasci, N.
dc.contributor.author Kaptanoglu, B.
dc.contributor.author Marangoz, C.
dc.date.accessioned 2019-08-16T11:50:30Z
dc.date.available 2019-08-16T11:50:30Z
dc.date.issued 1999
dc.identifier.issn 03276309 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/5607
dc.description.abstract Effects of calcium channel blocker flunarizine on spinal monosynaptic reflexes were investigated in spinal cats. Flunarizine was administered locally into the spinal cord (10, 50, 100 microM) and intraperitoneally (5, 10, 20 mg/kg). Adult cats (n = 10), weighing 1.5-3 kg were anesthetized with ketamine (50 mg/kg, i.m.) and artificially ventilated. Animals were spinalized at C1 level. A laminectomy was performed in the lumbosacral region. The ventral and dorsal roots of segment L5 were isolated and a pouch of skin was formed at the site of the dissection to allow the exposed tissues to be covered with liquid paraffin. The temperature was kept at 38.5 degrees C with a heating pad. A polyethylene cannula was introduced into the left carotid artery to monitor blood pressure, which was kept above 100 mmHg. The dorsal root of segment L5 was placed on a silver-silver chloride wire electrode for stimulation through an isolation unit. The reflex potentials were recorded from the ipsilateral L5 ventral root, mounted on a silver-silver chloride wire electrode. The systemic (5, 10, 20 mg/kg) and local (50 and 100 microM) dosages of cinnarizin derivative flunarizine significantly decreased the amplitude of reflex response (p < 0.05). Moreover, the latency of the monosynaptic reflexes was increased after administration of the drug (p < 0.05). Voltage-dependent calcium channels in the spinal cord may play an important role to regulate reflex respond.
dc.language.iso English
dc.rights info:eu-repo/semantics/closedAccess
dc.subject calcium channel blocking agent
dc.subject flunarizine
dc.subject animal
dc.subject article
dc.subject cat
dc.subject drug effect
dc.subject monosynaptic reflex
dc.subject physiology
dc.subject spinal cord
dc.subject Animals
dc.subject Calcium Channel Blockers
dc.subject Cats
dc.subject Flunarizine
dc.subject Reflex, Monosynaptic
dc.subject Spinal Cord
dc.title The effects of calcium channel blocker, flunarizine on spinal reflexes in the cats.
dc.title.alternative Effects of calcium channel blocker, flunarizine on spinal reflexes in the cats.
dc.type Article
dc.relation.journal Acta physiologica, pharmacologica et therapeutica latinoamericana : órgano de la Asociación Latinoamericana de Ciencias Fisiológicas y [de] la Asociación Latinoamericana de Farmacología
dc.identifier.volume 49
dc.identifier.issue 3
dc.identifier.startpage 119
dc.identifier.endpage 123
dc.relation.publicationCategory Uluslararası Hakemli Dergi
dc.identifier.index Scopus
dc.identifier.index WOS
dc.identifier.index PubMed


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