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Protective effect of pentoxifyllin on alcohol induced gastric mucosal damage in rats: Relation with prostoglandin and nitric oxide

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dc.contributor.author Kosekli, M.A.
dc.contributor.author Ozutemiz, O.
dc.contributor.author Karaoglu, A.O.
dc.contributor.author Erkus, M.
dc.contributor.author Tanyalcin, T.
dc.contributor.author Girgin, F.
dc.contributor.author Yonetci, N.
dc.contributor.author Batur, Y.
dc.date.accessioned 2019-08-16T11:49:47Z
dc.date.available 2019-08-16T11:49:47Z
dc.date.issued 1999
dc.identifier.issn 13004948 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/5575
dc.description.abstract Pentoxifylline (PTX) has been shown to increase tissue oxygen tension and improve tissue oxygen delivery. Early microcirculatory stasis is a major factor in gastric mucosal injury induced by ethanol in rats, PTX a methyl xanthine derivate prevents microcirculatory stasis and protects tissue by reducing tumour necrosis factor (TNF-α). This study investigated whether ptx induced protection involves nitric oxide mediated pathways or endogenous prostaglandins (PGs') production. Fifty-eight Swiss-Albino rats were divided into six groups and 2 ml of ethanol 98% was administered orogastrically to induce gastric mucosal injury. The animals were killed 30 minutes after gastric injury by cervical dislocation. In all groups, gastric mucosal injury was evaluated/measured by macroscopic and microscopic methods and glutathion ratio (GSH/GSSG) and malondialdehyde (MDA) levels in gastric tissue. One hour prior to ethanol administration the following were also administered Group 1: serum physiologic (SF) intraperitoneally (ip) 1 ml, Group 2:100 mg/kg PTX ip, Group 3:100 mg/kg PTX ip one hour following 1 ml SF subcutan (sc), Group 4: 100 mg/kg PTX ip one hour following 5 mg/kg indomethacin sc, Group 5: 100 mg/kg PTX ip one hour following 1 ml SF ip, Group 6:100 mg/kg PTX ip one hour after 60 mg/kg L-NAME (Nitric oxide synthesis inhibitor) ip subcutaneously. Results: PTX pretreatment prior to ethanol administration significantly reduced macroscopic and microscopic scores of gastric mucosal injury (10.6 ± 3.7 mm versus 27.5 ± 19.5, 0.88 ± 0.60 versus 1.87 ± 0.83, p < 0.05) respectively. PTX pretreatment also reduced MDA levels in gastric tissue 351.1 ± 94.0 versus 624.3 ± 234 mmol/gwettissue, (p < 0.01) but did not effect GSH/GSSG ratio. The experimental results of inhibition of endogenous PGs' synthesis was not affected by indomethacin, but administration of L-NAME significantly increased the gastric mucosal injury. Conclusion: PTX prevents ethanol induced gastric mucosal injury in rats. This effect is not related to the synthesis of prostaglandins, but does seem to be related to nitric oxide mediated pathways.
dc.language.iso Turkish
dc.subject Alcohol
dc.subject Experimental
dc.subject Gastric mucosa
dc.subject Pathogenesis
dc.subject Pentoxifyllin
dc.subject alcohol
dc.subject glutathione peroxidase
dc.subject indometacin
dc.subject malonaldehyde
dc.subject n(g) nitroarginine methyl ester
dc.subject nitric oxide
dc.subject pentoxifylline
dc.subject prostaglandin
dc.subject alcohol consumption
dc.subject animal experiment
dc.subject animal model
dc.subject animal tissue
dc.subject article
dc.subject controlled study
dc.subject drug mechanism
dc.subject nonhuman
dc.subject oxygen tissue level
dc.subject prostaglandin synthesis
dc.subject rat
dc.subject stomach mucosa lesion
dc.subject stomach protection
dc.title Protective effect of pentoxifyllin on alcohol induced gastric mucosal damage in rats: Relation with prostoglandin and nitric oxide
dc.type Article
dc.relation.journal Turkish Journal of Gastroenterology
dc.identifier.volume 10
dc.identifier.issue 4
dc.identifier.startpage 378
dc.identifier.endpage 384
dc.identifier.index Scopus

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