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Lipid peroxidation and glutathione levels after cortical injection of ferric chloride in rats: Effect of trimetazidine and deferoxamine

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dc.contributor.author Suzer, T.
dc.contributor.author Coskun, E.
dc.contributor.author Demir, S.
dc.contributor.author Tahta, K.
dc.date.accessioned 2019-08-16T11:49:01Z
dc.date.available 2019-08-16T11:49:01Z
dc.date.issued 2000
dc.identifier.issn 03009130 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/5539
dc.description.abstract Intracortical injection of iron salts causes seizures. Oxidation of lipids in neural membranes by reactive oxygen species is involved in the mechanism responsible for iron-induced seizures as a model of posttraumatic epilepsy. In this study, we examined the effect of trimetazidine (TMZ) and deferoxamine (DFO) on lipid peroxidation after cortical injection of 5 μl of an aqueous solution containing 100 mM of ferric chloride (FeC13) in rats. Animals were divided into four groups (n = 7 each) and treated as follows: group 1, saline injection into the cortex (control group); group 2, iron injection into the cortex (injury group); group 3, iron injection into the cortex plus TMZ; group 4, iron injection into the cortex plus DFO. The animals were killed 3 h after injections, and the levels of malondialdehyde (MDA), a lipid peroxidation product, and reduced glutathione (GSH) were measured. A significant elevation of MDA was observed in group 2 (P < 0.05). MDA levels were found to be lower in both the TMZ-treated (P < 0.05) and DFO-treated (P < 0.05) groups than in the injury group. Tissue GSH levels were significantly decreased in group 2 (P < 0.05). GSH levels were increased in the TMZ-treated (P < 0.05) and DFO-treated (P < 0.05) groups compared to the injury group. The results of our study suggest that lipid peroxidation is a critical event in iron-induced epilepsy and that treatment with TMZ and DFO is effective in preventing the formation of free radicals and reducing lipoperoxides in brain tissue.
dc.language.iso English
dc.subject Deferoxamine
dc.subject Glutathione
dc.subject Iron-induced epilepsy
dc.subject Lipid peroxidation
dc.subject Trimetazidine
dc.subject deferoxamine
dc.subject ferric chloride
dc.subject free radical
dc.subject glutathione
dc.subject lipid peroxide
dc.subject malonaldehyde
dc.subject reactive oxygen metabolite
dc.subject sodium chloride
dc.subject trimetazidine
dc.subject animal experiment
dc.subject animal model
dc.subject animal tissue
dc.subject article
dc.subject brain cortex
dc.subject controlled study
dc.subject lipid peroxidation
dc.subject male
dc.subject nerve membrane
dc.subject nonhuman
dc.subject priority journal
dc.subject rat
dc.subject seizure
dc.subject traumatic epilepsy
dc.subject Analysis of Variance
dc.subject Animals
dc.subject Brain
dc.subject Chelating Agents
dc.subject Epilepsy
dc.subject Ferrous Compounds
dc.subject Lipid Peroxidation
dc.subject Male
dc.subject Malondialdehyde
dc.subject Random Allocation
dc.subject Rats
dc.subject Vasodilator Agents
dc.title Lipid peroxidation and glutathione levels after cortical injection of ferric chloride in rats: Effect of trimetazidine and deferoxamine
dc.type Article
dc.relation.journal Research in Experimental Medicine
dc.identifier.volume 199
dc.identifier.issue 4
dc.identifier.startpage 223
dc.identifier.endpage 229
dc.identifier.index Scopus


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