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Cardiovascular safety of cocaine anaesthesia in the presence of adrenaline during septal surgery

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dc.contributor.author Kara, Cüneyt Orhan
dc.contributor.author Kaftan, Asuman
dc.contributor.author Atalay, Habip
dc.contributor.author Pınar, Hilmi Şafak
dc.contributor.author Öǧmen, Gülsen
dc.date.accessioned 2019-08-16T11:47:12Z
dc.date.available 2019-08-16T11:47:12Z
dc.date.issued 2001
dc.identifier.issn 03816605 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/5443
dc.description.abstract Objective: The purpose of this study was to investigate the possible cardiovascular side effects of 4% cocaine solution in the presence of adrenaline during septal surgery. Method: Sixty adult patients undergoing elective septal surgery with local anaesthesia were included in the study. Noses were packed with 5-mL 4% cocaine (200-mg) solution on cotton pledgets, which were left in the nose for 15 minutes. Then, 10 mL of local anaesthetic (lidocaine 2% and adrenaline 1:100,000) were infiltrated in septal mucosa, and 15 minutes later, the surgical procedure was initiated. At the beginning of the operation, intervals from 12-lead surface electrocardiograms and vital signs including blood pressures and heart rate were recorded as a baseline. All measurements were repeated just before local anaesthetic infiltration, just before the beginning of the surgical procedure, and, finally, at the end of the operation. All four measurements and electrocardiographic tracings were examined. Systolic and diastolic blood pressures and QT parameters, RR intervals, and heart rates obtained from electrocardiogram were compared statistically with repeated-measures analysis of variance. Results: No statistically significant difference was found among all four staged measurements. None of the patients developed tachycardia, hypertension, hypotension, or any chest pain. In electrocardiogram tracings, no sinus tachycardia depression, elevation, or bundle branch block was noted. Conclusion: This study shows that concomitant use of cocaine and adrenaline in the proper concentration and volume and in a carefully screened patient group was safe for the cardiovascular system.
dc.language.iso English
dc.relation.isversionof 10.2310/7070.2001.20197
dc.rights info:eu-repo/semantics/closedAccess
dc.subject Anaesthesia
dc.subject Cardiovascular side effects
dc.subject Cocaine
dc.subject adrenalin
dc.subject cocaine
dc.subject lidocaine
dc.subject adult
dc.subject analysis of variance
dc.subject article
dc.subject cardiotoxicity
dc.subject cardiovascular system
dc.subject drug absorption
dc.subject drug safety
dc.subject electrocardiogram
dc.subject female
dc.subject heart bundle branch block
dc.subject human
dc.subject hypertension
dc.subject hypotension
dc.subject local anesthesia
dc.subject major clinical study
dc.subject male
dc.subject nose surgery
dc.subject patient selection
dc.subject priority journal
dc.subject sinus tachycardia
dc.subject tachycardia
dc.subject thorax pain
dc.subject topical anesthesia
dc.subject vasoconstriction
dc.subject Adult
dc.subject Anesthesia, Local
dc.subject Anesthetics, Combined
dc.subject Blood Pressure
dc.subject Cardiovascular System
dc.subject Electrocardiography
dc.subject Epinephrine
dc.subject Female
dc.subject Heart Rate
dc.subject Humans
dc.subject Male
dc.subject Middle Aged
dc.subject Nasal Septum
dc.subject Otorhinolaryngologic Surgical Procedures
dc.subject Solutions
dc.title Cardiovascular safety of cocaine anaesthesia in the presence of adrenaline during septal surgery
dc.type Article
dc.relation.journal Journal of Otolaryngology
dc.contributor.authorID 0000-0003-2219-4283
dc.contributor.authorID 0000-0001-5888-349X
dc.identifier.volume 30
dc.identifier.issue 3
dc.identifier.startpage 145
dc.identifier.endpage 148
dc.relation.publicationCategory Uluslararası Hakemli Dergi
dc.identifier.index Scopus
dc.identifier.index WOS
dc.identifier.index PubMed

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