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Is Doppler tissue velocity during early left ventricular filling preload independent?

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dc.contributor.author Yalçin, F.
dc.contributor.author Kaftan, A.
dc.contributor.author Muderrisoǧlu, H.
dc.contributor.author Korkmaz, M.E.
dc.contributor.author Flachskampf, F.
dc.contributor.author Garcia, M.
dc.contributor.author Thomas, J.D.
dc.date.accessioned 2019-08-16T11:46:02Z
dc.date.available 2019-08-16T11:46:02Z
dc.date.issued 2002
dc.identifier.issn 13556037 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/5384
dc.description.abstract Background: Transmitral Doppler flow indices are used to evaluate diastolic function. Recently, velocities measured by Doppler tissue imaging have been used as an index of left ventricular relaxation. Objective: To determine whether Doppler tissue velocities are influenced by alterations in preload. Methods: Left ventricular preload was altered in 17 patients (all men, mean (SD) age, 49 (8) years) during echocardiographic measurements of left ventricular end diastolic volume, maximum left atrial area, peak early Doppler filling velocity, and left ventricular myocardial velocities during early filling. Preload altering manoeuvres included Trendelenberg (stage 1), reverse Trendelenberg (stage 2), and amyl nitrate (stage 3). Systolic blood pressure was measured at each stage. Results: In comparison with baseline, left ventricular end diastolic volume (p = 0.001), left atrial area (p = 0.003), peak early mitral Doppler filling velocity (p = 0.01), and systolic blood pressures (p = 0.001) were all changed by preload altering manoeuvres. Only left ventricular myocardial velocity during early filling remained unchanged by these manoeuvres. Conclusions: In contrast to standard transmitral Doppler filling indices, Doppler tissue early diastolic velocities are not significantly affected by physiological manoeuvres that alter preload. Thus Doppler tissue velocities during early left ventricular diastole may provide a better index of diastolic function in cardiac patients by providing a preload independent assessment of left ventricular filling.
dc.language.iso English
dc.subject adult
dc.subject article
dc.subject blood volume
dc.subject clinical article
dc.subject correlation analysis
dc.subject diastole
dc.subject Doppler flowmeter
dc.subject echocardiography
dc.subject heart failure
dc.subject heart left ventricle function
dc.subject heart left ventricle performance
dc.subject heart preload
dc.subject heart ventricle filling
dc.subject human
dc.subject intermethod comparison
dc.subject male
dc.subject priority journal
dc.subject NASA Discipline Cardiopulmonary
dc.subject Non-NASA Center
dc.subject Blood Flow Velocity
dc.subject Blood Pressure
dc.subject Coronary Arteriosclerosis
dc.subject Coronary Circulation
dc.subject Diastole
dc.subject Echocardiography, Doppler
dc.subject Humans
dc.subject Magnetic Resonance Angiography
dc.subject Male
dc.subject Middle Aged
dc.subject Stroke Volume
dc.subject Ventricular Dysfunction, Left
dc.subject Ventricular Function, Left
dc.title Is Doppler tissue velocity during early left ventricular filling preload independent?
dc.type Article
dc.relation.journal Heart
dc.identifier.volume 87
dc.identifier.issue 4
dc.identifier.startpage 336
dc.identifier.endpage 339
dc.identifier.index Scopus


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