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Basal serum nitric oxide levels in patients with type 2 diabetes mellitus and different stages of retinopathy

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dc.contributor.author Özden, S.
dc.contributor.author Tatlipinar, S.
dc.contributor.author Biçer, N.
dc.contributor.author Yaylali, V.
dc.contributor.author Yildirim, C.
dc.contributor.author Özbay, D.
dc.contributor.author Güner, G.
dc.date.accessioned 2019-08-16T11:44:32Z
dc.date.available 2019-08-16T11:44:32Z
dc.date.issued 2003
dc.identifier.issn 00084182 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/5309
dc.description.abstract Purpose: To compare the basal serum levels of nitric oxide (NO) in patients with type 2 diabetes mellitus and different stages of diabetic retinopathy (DR) with the levels in nondiabetic control subjects. Methods: The 39 patients with type 2 diabetes included in this study were divided by stage of DR into 3 groups: group A, those without DR; group B, those with background/preproliferative DR; and group C, those with proliferative DR. Eleven non-diabetic subjects made up the control group (group D). The NO concentration was determined indirectly by measuring the serum level of nitrite (NO2 -) plus nitrate (NO3 -) (NO x = NO2 - plus NO3 -) using a spectrophotometric method based on the Griess reaction. Results: The patients with type 2 diabetes had significantly higher levels of serum NO x than the nondiabetic controls (p = 0.0001). In addition, the levels in the patients with proliferative DR were significantly higher (p = 0.002) than the levels in the patients with nonproliferative or no DR. Conclusion: Our study demonstrated both elevated levels of serum NOx in diabetic patients as compared with nondiabetic controls and a relationship between NOx and DR severity. Hence, abnormal NO metabolism may have a role in the pathogenesis of DR.
dc.language.iso English
dc.publisher Elsevier B.V.
dc.relation.isversionof 10.1016/S0008-4182(03)80051-0
dc.subject Diabetes mellitus
dc.subject Diabetic retinopathy
dc.subject Nitric oxide
dc.subject nitric oxide
dc.subject article
dc.subject blood level
dc.subject clinical article
dc.subject controlled study
dc.subject correlation analysis
dc.subject diabetic retinopathy
dc.subject disease activity
dc.subject disease severity
dc.subject human
dc.subject non insulin dependent diabetes mellitus
dc.subject pathogenesis
dc.subject spectrophotometry
dc.title Basal serum nitric oxide levels in patients with type 2 diabetes mellitus and different stages of retinopathy
dc.type Article
dc.relation.journal Canadian Journal of Ophthalmology
dc.identifier.volume 38
dc.identifier.issue 5
dc.identifier.startpage 393
dc.identifier.endpage 396
dc.identifier.index Scopus

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