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Cytogenetic studies in patients with reproductive failure

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dc.contributor.author Düzcan, Füsun
dc.contributor.author Atmaca, Münevver
dc.contributor.author Çetin, Gökhan Ozan
dc.contributor.author Baǧcı, Hüseyin
dc.date.accessioned 2019-08-16T11:44:30Z
dc.date.available 2019-08-16T11:44:30Z
dc.date.issued 2003
dc.identifier.issn 00016349 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/5307
dc.description.abstract Background. Cytogenetic studies in patients with reproductive failure Aim. To investigate the contribution of chromosomal abnormalities in sub fertility and in couples with repeated abortions. Methods. Hundred and 13 couples who had at least two or more spontaneous abortions and 65 women and 63 men with infertility were analyzed cytogenetically. Results. Major chromosomal rearrangements were found in 8% and minor variants in 6% in the study population. Major chromosomal aberrations were judged to explain 4.9% of recurrent abortions and 13% of infertility. Chromosomal abnormalities in infertile men occurred in 5% and in infertile women in 21.5%. The chromosomal abnormalities were structural (57%), numerical (18%) or mosaics (25%). Conclusions. Chromosomal aberrations in recurrent abortions are mostly structural ones and those in female infertility mosaicism of sex chromosomes. Turner's syndrome, Turner variants and XY females are detected as a cause of female infertility. The structural and numerical aberrations of either sex or autosomal chromosomes were found in infertile men.
dc.language.iso English
dc.relation.isversionof 10.1034/j.1600-0412.2003.820109.x
dc.rights info:eu-repo/semantics/closedAccess
dc.subject Chromosomal abnormalities
dc.subject Infertility
dc.subject Recurrent abortion
dc.subject Reproductive failure
dc.subject article
dc.subject autosomal disorder
dc.subject chromosome aberration
dc.subject chromosome analysis
dc.subject chromosome mosaicism
dc.subject chromosome number
dc.subject chromosome structure
dc.subject chromosome variant
dc.subject controlled study
dc.subject cytogenetics
dc.subject female
dc.subject female infertility
dc.subject human
dc.subject karyotype
dc.subject karyotype 46,XY
dc.subject major clinical study
dc.subject male
dc.subject male infertility
dc.subject numerical chromosome aberration
dc.subject population research
dc.subject priority journal
dc.subject recurrent abortion
dc.subject reproductive health
dc.subject sex chromosome
dc.subject structural chromosome aberration
dc.subject subfertility
dc.subject Turner syndrome
dc.subject Abortion, Spontaneous
dc.subject Chromosome Aberrations
dc.subject Chromosome Banding
dc.subject Chromosome Disorders
dc.subject Chromosomes, Human, 1-3
dc.subject Chromosomes, Human, 6-12 and X
dc.subject Chromosomes, Human, Y
dc.subject Female
dc.subject Gene Rearrangement
dc.subject Humans
dc.subject Infertility, Female
dc.subject Infertility, Male
dc.subject Inversion, Chromosome
dc.subject Karyotyping
dc.subject Male
dc.subject Polymorphism, Genetic
dc.title Cytogenetic studies in patients with reproductive failure
dc.type Article
dc.relation.journal Acta Obstetricia et Gynecologica Scandinavica
dc.identifier.volume 82
dc.identifier.issue 1
dc.identifier.startpage 53
dc.identifier.endpage 56
dc.relation.publicationCategory Uluslararası Hakemli Dergi
dc.identifier.index Scopus
dc.identifier.index WOS
dc.identifier.index PubMed


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