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Usefulness of procalcitonin for diagnosis of sepsis in the intensive care unit

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dc.contributor.author Bacli, C.
dc.contributor.author Sungurtekin, H.
dc.contributor.author Gürses, E.
dc.contributor.author Sungurtekin, U.
dc.contributor.author Kaptanoǧlu, B.
dc.date.accessioned 2019-08-16T11:44:14Z
dc.date.available 2019-08-16T11:44:14Z
dc.date.issued 2003
dc.identifier.issn 13648535 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/5289
dc.description.abstract Introduction. The diagnosis of sepsis in critically ill patients is challenging because traditional markers of infection are often misleading. The present study was conducted to determine the procalcitonin level at early diagnosis (and differentiation) in patients with systemic inflammatory response syndrome (SIRS) and sepsis, in comparison with C-reactive protein, IL-2, IL-6, IL-8 and tumour necrosis factor-α. Method. Thirty-three intensive care unit patients were diagnosed with SIRS, sepsis or septic shock, in accordance with the American College of Chest Physicians/Society of Critical Care Medicine consensus criteria. Blood samples were taken on the first and second day of hospitalization, and on the day of discharge or on the day of death. For multiple group comparisons one-way analysis of variance was applied, with post hoc comparison. Sensitivity, specificity and predictive values for PCT and each cytokine studied were calculated. Results. PCT, IL-2 and IL-8 levels increased in parallel with the severity of the clinical condition of the patient. PCT exhibited a greatest sensitivity (85%) and specificity (91%) in differentiating patients with SIRS from those with sepsis. With respect to positive and negative predictive values, PCT markedly exceeded other variables. Discussion. In the present study PCT was found to be a more accurate diagnostic parameter for differentiating SIRS and sepsis, and therefore daily determinations of PCT may be helpful in the follow up of critically ill patients.
dc.language.iso English
dc.relation.isversionof 10.1186/cc1843
dc.subject C-reactive protein
dc.subject Cytokine
dc.subject Diagnosis
dc.subject Procalcitonin
dc.subject Sepsis
dc.subject C reactive protein
dc.subject cytokine
dc.subject interleukin 2
dc.subject interleukin 6
dc.subject interleukin 8
dc.subject procalcitonin
dc.subject tumor necrosis factor alpha
dc.subject adult
dc.subject aged
dc.subject analysis of variance
dc.subject blood sampling
dc.subject clinical article
dc.subject controlled study
dc.subject critical illness
dc.subject death
dc.subject diagnostic accuracy
dc.subject diagnostic value
dc.subject differential diagnosis
dc.subject disease marker
dc.subject disease severity
dc.subject early diagnosis
dc.subject female
dc.subject follow up
dc.subject Gram negative bacterium
dc.subject Gram positive bacterium
dc.subject hospital discharge
dc.subject hospitalization
dc.subject human
dc.subject intensive care unit
dc.subject intermethod comparison
dc.subject male
dc.subject medical society
dc.subject patient care
dc.subject prediction
dc.subject priority journal
dc.subject review
dc.subject sensitivity and specificity
dc.subject sepsis
dc.subject septic shock
dc.subject systemic inflammatory response syndrome
dc.subject Adult
dc.subject Aged
dc.subject Area Under Curve
dc.subject Biological Markers
dc.subject C-Reactive Protein
dc.subject Calcitonin
dc.subject Female
dc.subject Humans
dc.subject Intensive Care
dc.subject Interleukin-2
dc.subject Interleukin-6
dc.subject Interleukin-8
dc.subject Male
dc.subject Middle Aged
dc.subject Predictive Value of Tests
dc.subject Protein Precursors
dc.subject Shock, Septic
dc.subject Systemic Inflammatory Response Syndrome
dc.subject Tumor Necrosis Factor-alpha
dc.title Usefulness of procalcitonin for diagnosis of sepsis in the intensive care unit
dc.type Review
dc.relation.journal Critical Care
dc.identifier.volume 7
dc.identifier.issue 1
dc.identifier.startpage 85
dc.identifier.endpage 90
dc.identifier.index Scopus

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