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Mal de Meleda: A new geographical localization in Anatolia

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dc.contributor.author Ergin, Ş.
dc.contributor.author Şanli Erdoǧan, B.
dc.contributor.author Aktan, Ş.
dc.date.accessioned 2019-08-16T11:44:12Z
dc.date.available 2019-08-16T11:44:12Z
dc.date.issued 2003
dc.identifier.issn 10188665 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/5287
dc.description.abstract Background: Mal de Meleda (MDM) is an autosomal recessive form of palmoplantar keratoderma first described on the Dalmatian island of Meleda. MDM has been observed in many other countries so that the origin of the MDM gene may be elsewhere than in Meleda. Objective: After identification of the first MDM patient during a medical visit, a study was planned to reveal other families with MDM in the Köprüçay region in Anatolia. Methods: The patient was interviewed with a questionnaire including a pedigree drawing. All the subsequent cases reported to be of MDM were visited for clinical examination and pedigree drawings. Results: Thirty-nine patients, 8 families and 2 additional cases with MDM were identified in a 50-km(2)mountainous region in Köprüçay canyon in Anatolia. The prevalent clinical features were nail involvement (80%), 'glove-and-sock' distribution of the keratoderma (60%), edema on the hands/feet (60%), conical tapering of the fingertips (60%) and hyperhidrosis on the palms and soles (50%). Conclusion: To our knowledge, this is the largest series reported. The relationship between the patients in Meleda and those in Anatolia awaits discovery by further researches that will be carried out with the collaboration of dermatology, genetics and medical history departments. Copyright © 2003 S. Karger AG, Basel.
dc.language.iso English
dc.relation.isversionof 10.1159/000068464
dc.subject Anatolia
dc.subject Hereditary palmoplantar keratoderma
dc.subject Mal de Meleda
dc.subject adolescent
dc.subject adult
dc.subject article
dc.subject child
dc.subject clinical article
dc.subject clinical examination
dc.subject clinical feature
dc.subject controlled study
dc.subject edema
dc.subject familial disease
dc.subject female
dc.subject finger malformation
dc.subject foot disease
dc.subject foot sole
dc.subject hand disease
dc.subject hand palm
dc.subject health care planning
dc.subject human
dc.subject hyperhidrosis
dc.subject infant
dc.subject interview
dc.subject keratosis palmoplantaris
dc.subject mal de meleda
dc.subject male
dc.subject pedigree
dc.subject prevalence
dc.subject priority journal
dc.subject Turkey (republic)
dc.subject Adolescent
dc.subject Adult
dc.subject Child
dc.subject Child, Preschool
dc.subject Consanguinity
dc.subject Female
dc.subject Humans
dc.subject Infant
dc.subject Keratoderma, Palmoplantar
dc.subject Male
dc.subject Middle Aged
dc.subject Pedigree
dc.subject Turkey
dc.title Mal de Meleda: A new geographical localization in Anatolia
dc.type Article
dc.relation.journal Dermatology
dc.identifier.volume 206
dc.identifier.issue 2
dc.identifier.startpage 124
dc.identifier.endpage 130
dc.identifier.index Scopus

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