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Protective role of glutathione S-transferase P1 (GSTP1) Val105Val genotype in patients with bronchial asthma

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dc.contributor.author Aynacioglu, A.S.
dc.contributor.author Nacak, M.
dc.contributor.author Filiz, A.
dc.contributor.author Ekinci, E.
dc.contributor.author Roots, I.
dc.date.accessioned 2019-08-16T11:41:58Z
dc.date.available 2019-08-16T11:41:58Z
dc.date.issued 2004
dc.identifier.issn 03065251 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/5142
dc.description.abstract Background: Glutathione S-transferase P1 (GSTP1), the abundant isoform of glutathione S-transferases (GSTs) in lung epithelium, plays an important role in cellular protection against oxidative stress and toxic foreign chemicals. It has been suggested that polymorphisms in the GSTP1 gene are associated with asthma and related phenotypes. As significant interindividual and interethnic differences exist in the distribution of xenobiotic-metabolizing enzymes, we have studied the GSTP1 Ile105Val polymorphism in patients with asthma in a Turkish sample. Methods: GSTP1 Ile105Val polymorphism in exon 5 was determined in 210 patients with asthma (112 extrinsic and 108 intrinsic) and 265 control individuals without lung diseases and without history of allergy or atopy, using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) techniques. Results: The proportion of GSTP1 Val105 homozygotes was significantly lower in the patients with asthma than in the control individuals (3.8% vs 12.1%). The odds ratio for GSTP1 Val105 homozygotes vs all other genotypes was 0.29 (95%CL 0.13-0.64, p = 0.01) for asthmatics. The distribution of GSTP1 Ile105Val genotypes and the frequency of GSTP1 Val105Val homozygotes (3.7% vs 3.9%) was not significantly different between extrinsic and intrinsic asthmatics. Conclusion: These results suggest a significant association between GSTP1 Ile105Val polymorphism and susceptibility to asthma and that the GSTP1 Val105Val genotype may be protective against developing this disease.
dc.language.iso English
dc.relation.isversionof 10.1046/j.1365-2125.2003.01975.x
dc.subject Asthma
dc.subject GSTP1
dc.subject Molecular genetics
dc.subject Polymorphism
dc.subject glutathione transferase
dc.subject isoenzyme
dc.subject isoleucine
dc.subject valine
dc.subject adolescent
dc.subject adult
dc.subject allergy
dc.subject anamnesis
dc.subject article
dc.subject asthma
dc.subject atopy
dc.subject confidence interval
dc.subject controlled study
dc.subject enzyme activity
dc.subject exon
dc.subject female
dc.subject genetic polymorphism
dc.subject genotype
dc.subject health status
dc.subject homozygosity
dc.subject human
dc.subject lung disease
dc.subject major clinical study
dc.subject male
dc.subject polymerase chain reaction
dc.subject priority journal
dc.subject protection
dc.subject restriction fragment length polymorphism
dc.subject risk assessment
dc.subject sampling
dc.subject statistical significance
dc.subject Turkey (republic)
dc.subject Adolescent
dc.subject Adult
dc.subject Aged
dc.subject Female
dc.subject Genetic Predisposition to Disease
dc.subject Genotype
dc.subject Glutathione S-Transferase pi
dc.subject Glutathione Transferase
dc.subject Homozygote
dc.subject Humans
dc.subject Isoenzymes
dc.subject Male
dc.subject Middle Aged
dc.subject Polymorphism, Genetic
dc.subject Polymorphism, Restriction Fragment Length
dc.title Protective role of glutathione S-transferase P1 (GSTP1) Val105Val genotype in patients with bronchial asthma
dc.type Article
dc.relation.journal British Journal of Clinical Pharmacology
dc.identifier.volume 57
dc.identifier.issue 2
dc.identifier.startpage 213
dc.identifier.endpage 217
dc.identifier.index Scopus

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