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Effect of sulfite on cognitive function in normal and sulfite oxidase deficient rats

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dc.contributor.author Küçükatay, Vural.
dc.contributor.author Savcioglu, F.
dc.contributor.author Hacioglu, G.
dc.contributor.author Yargiçoglu, P.
dc.contributor.author Agar, A.
dc.date.accessioned 2019-08-16T11:39:38Z
dc.date.available 2019-08-16T11:39:38Z
dc.date.issued 2005
dc.identifier.issn 0892-0362
dc.identifier.uri https://hdl.handle.net/11499/4980
dc.identifier.uri https://doi.org/10.1016/j.ntt.2004.10.002
dc.description.abstract Sulfites, which are commonly used as preservatives, are continuously formed in the body during metabolism of sulfur-containing amino acids. Sulfite is oxidized to sulfate ion by sulfite oxidase (SOX, EC. The aim of this study was to investigate the possible toxic effects of sulfite on neurons by measuring active avoidance learning in normal and SOX-deficient rats. For this purpose, male albino rats used in this study were divided into eight groups such as control group (C), sulfite group (25 mg/kg) (S), vitamin E group (50 mg/kg) (E), sulfite (25 mg/kg)+vitamin E group (50 mg/kg) (SE), SOX-deficient group (D), deficient+vitamin E group (50 mg/kg) (DE), deficient+sulfite group (25 mg/kg) (DS) and deficient+sulfite (25 mg/kg)+vitamin E group (50 mg/kg) (DSE). Sulfite-induced impairment of active avoidance learning in SOX-deficient rats but not in normal rats. Sulfite had no effect on hippocampus TBARS levels in SOX normal groups. In SOX-deficient rats, TBARS levels were found to be significantly increased with sulfite exposure. Vitamin E reversed the observed detrimental effects of sulfite in the SOX-deficient rats on their hippocampal TBARS but not on their active avoidance learning. In conclusion, sulfite has neurotoxic effects in sulfite oxidase deficient rats, but this effect may not depend on oxidative stress. © 2004 Elsevier Inc. All rights reserved. en_US
dc.language.iso en en_US
dc.relation.ispartof Neurotoxicology and Teratology en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Cognition en_US
dc.subject Food additives en_US
dc.subject Oxidative stress en_US
dc.subject Rat en_US
dc.subject Sulfite en_US
dc.subject alpha tocopherol en_US
dc.subject sulfite en_US
dc.subject sulfite oxidase en_US
dc.subject thiobarbituric acid reactive substance en_US
dc.subject animal experiment en_US
dc.subject animal tissue en_US
dc.subject article en_US
dc.subject avoidance behavior en_US
dc.subject cognition en_US
dc.subject controlled study en_US
dc.subject enzyme activity en_US
dc.subject enzyme deficiency en_US
dc.subject hippocampus en_US
dc.subject learning disorder en_US
dc.subject lipid peroxidation en_US
dc.subject male en_US
dc.subject motor performance en_US
dc.subject nerve cell en_US
dc.subject nonhuman en_US
dc.subject oxidative stress en_US
dc.subject priority journal en_US
dc.subject protein determination en_US
dc.subject rat en_US
dc.subject toxicity en_US
dc.subject Animals en_US
dc.subject Antioxidants en_US
dc.subject Avoidance Learning en_US
dc.subject Behavior, Animal en_US
dc.subject Cysteine en_US
dc.subject Drug Interactions en_US
dc.subject Hippocampus en_US
dc.subject Liver en_US
dc.subject Male en_US
dc.subject Motor Activity en_US
dc.subject Oxidoreductases Acting on Sulfur Group Donors en_US
dc.subject Random Allocation en_US
dc.subject Rats en_US
dc.subject Sulfites en_US
dc.subject Thiobarbituric Acid Reactive Substances en_US
dc.subject Time Factors en_US
dc.subject Vitamin E en_US
dc.title Effect of sulfite on cognitive function in normal and sulfite oxidase deficient rats en_US
dc.type Article en_US
dc.identifier.volume 27 en_US
dc.identifier.issue 1 en_US
dc.identifier.startpage 47
dc.identifier.startpage 47 en_US
dc.identifier.endpage 54 en_US
dc.authorid 0000-0002-6850-6281
dc.identifier.doi 10.1016/j.ntt.2004.10.002
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.identifier.pmid 15681120 en_US
dc.identifier.scopus 2-s2.0-12844259533 en_US
dc.identifier.wos WOS:000227016300005 en_US

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