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No association of the CAG repeat length in exon 1 of the androgen receptor gene with idiopathic infertility in Turkish men: Implications and literature review

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dc.contributor.author Tufan, Ahmet Çevik
dc.contributor.author Şatıroğlu-Tufan, Naciye Lale
dc.contributor.author Aydınuraz, Batu
dc.contributor.author Şatıroğlu, M. Hakan
dc.contributor.author Aydos, Kaan
dc.contributor.author Bağcı, Hüseyin
dc.date.accessioned 2019-08-16T11:38:13Z
dc.date.available 2019-08-16T11:38:13Z
dc.date.issued 2005
dc.identifier.issn 0040-8727
dc.identifier.uri https://hdl.handle.net/11499/4868
dc.identifier.uri https://doi.org/10.1620/tjem.206.105
dc.description.abstract While the correlation between the CAG repeat length of the androgen receptor (AR) gene and idiopathic male infertility is still unclear, ethnic background of the population studied may play an important role in this association. The objective of this study was to determine whether changes in the CAG repeat length are associated with spermatogenic defects in Turkish infertile men. Reproductive hormone concentrations and the CAG repeat length in exon 1 of the AR gene in 47 idiopathic infertile men and 32 fertile controls were analyzed. The mean serum luteinising hormone (LH) and follicle stimulating hormone (FSH) levels were significantly higher in the infertile group than those of the control group (p < 0.0001 for both comparisons), whereas the mean serum testosterone level in the infertile group did not differ significantly from that in the control group (p = 0.16). The mean CAG repeat length of the AR gene in the infertile group did not differ significantly from that in the control group (22.28 ± 0.37 vs 22.41 ± 0.54, respectively; p = 0.84). In addition, the frequency of having a CAG repeat number (? 24) was also comparable between the infertile patients and fertile controls (31.9% vs 40.6%, respectively; p = 0.21). In conclusion, reproductive hormones with elevated LH and FSH, and normal or low testosterone levels were suggestive of partial impairment of testicular function. However, no statistically significant relationship between the length of the CAG repeat and idiopathic impaired sperm production was observed in the Turkish population studied. These results support the findings of previously published European studies, but are contrary to the findings from Caucasian and North American population studies. Thus, ethnicity and genetic backgrounds seem to be important in this association, and studies from a variety of different ethnic and genetic backgrounds using comparable patient subgroups are valuable to further evaluate this association. © 2005 Tohoku University Medical Press. en_US
dc.language.iso en en_US
dc.relation.ispartof Tohoku Journal of Experimental Medicine en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Androgen receptor gene en_US
dc.subject CAG repeat en_US
dc.subject Defective spermatogenesis en_US
dc.subject Male infertility en_US
dc.subject adenine en_US
dc.subject androgen receptor en_US
dc.subject cytosine en_US
dc.subject DNA en_US
dc.subject follitropin en_US
dc.subject guanine en_US
dc.subject luteinizing hormone en_US
dc.subject testosterone en_US
dc.subject adult en_US
dc.subject article en_US
dc.subject azoospermia en_US
dc.subject Caucasian en_US
dc.subject cell structure en_US
dc.subject clinical article en_US
dc.subject concentration (parameters) en_US
dc.subject controlled study en_US
dc.subject correlation analysis en_US
dc.subject DNA determination en_US
dc.subject ethnic difference en_US
dc.subject ethnology en_US
dc.subject Europe en_US
dc.subject exon en_US
dc.subject follitropin blood level en_US
dc.subject gene frequency en_US
dc.subject genetic association en_US
dc.subject genetic variability en_US
dc.subject human en_US
dc.subject human cell en_US
dc.subject idiopathic disease en_US
dc.subject luteinizing hormone blood level en_US
dc.subject male en_US
dc.subject male infertility en_US
dc.subject North America en_US
dc.subject oligospermia en_US
dc.subject population genetics en_US
dc.subject spermatogenesis en_US
dc.subject spermatozoon motility en_US
dc.subject statistical significance en_US
dc.subject testis function en_US
dc.subject testosterone blood level en_US
dc.subject trinucleotide repeat en_US
dc.subject Turkey (republic) en_US
dc.subject Adult en_US
dc.subject Aged en_US
dc.subject Base Sequence en_US
dc.subject Exons en_US
dc.subject Humans en_US
dc.subject Infertility, Male en_US
dc.subject Male en_US
dc.subject Middle Aged en_US
dc.subject Receptors, Androgen en_US
dc.subject Repetitive Sequences, Nucleic Acid en_US
dc.subject Turkey en_US
dc.title No association of the CAG repeat length in exon 1 of the androgen receptor gene with idiopathic infertility in Turkish men: Implications and literature review en_US
dc.type Article en_US
dc.identifier.volume 206 en_US
dc.identifier.issue 2 en_US
dc.identifier.startpage 105
dc.identifier.startpage 105 en_US
dc.identifier.endpage 115 en_US
dc.authorid 0000-0001-9399-0960
dc.identifier.doi 10.1620/tjem.206.105
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.identifier.pmid 15888966 en_US
dc.identifier.scopus 2-s2.0-21244465941 en_US
dc.identifier.wos WOS:000228824400004 en_US

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