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Does melatonin protect or treat brain damage from traumatic oxidative stress?

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dc.contributor.author Kerman, M.
dc.contributor.author Cirak, B.
dc.contributor.author Ozguner, M.F.
dc.contributor.author Dagtekin, A.
dc.contributor.author Sutcu, R.
dc.contributor.author Altuntas, I.
dc.contributor.author Delibas, N.
dc.date.accessioned 2019-08-16T11:38:10Z
dc.date.available 2019-08-16T11:38:10Z
dc.date.issued 2005
dc.identifier.issn 0014-4819
dc.identifier.uri https://hdl.handle.net/11499/4864
dc.identifier.uri https://doi.org/10.1007/s00221-005-2338-2
dc.description.abstract A variety of experimental studies have demonstrated the neuroprotective effects of melatonin, based on its antioxidant activity. In a prospective randomized study, the effects of melatonin were investigated in experimental head trauma-induced oxidative stress in rabbits. The experimental study was performed on 30 rabbits. The animals were divided into three groups. Group I (sham procedure): a right parietal craniotomy was performed on each animal, and the dura mater was left intact. Group II: experimental brain trauma (EBT) was performed on each animal using a 1 cm inner diameter × 10 cm long glass tube, through which a 20 g weight (0.5 cm diameter) was dropped onto the brain at the craniotomy site, causing a contusional head trauma. Group III: the same EBT model was performed, but 2.5 mg/kg melatonin was injected intraperitoneally four times (total dose 10 mg/kg); these injections were performed 20 min before the operation, during the trauma, 1 h later and 2 h later. The rabbits were sacrificed after the EBT at 24 h after the brain trauma. The activities of the three principal antioxidant enzymes-catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px)-were determined, and the levels of malondialdehyde (MDA), a product of lipid peroxidation, and glutathione (GSH) were measured in brain homogenates. MDA levels were found to be higher in the EBT group than in the EBT+melatonin group or the sham procedure group. The SOD activity was found to be higher in the EBT group than in the sham procedure group. Enzymatic parameters (except for SOD) were significantly higher in melatonin-treated animals than in EBT animals. GSH levels in melatonin-treated animals were decreased compared with EBT animals. In conclusion, the data indicate that melatonin protects against free radical-mediated oxidative changes in brain tissue by boosting antioxidant enzymes, and in particular lowering lipid peroxidation in rabbits with EBT. © Springer-Verlag 2005. en_US
dc.language.iso en en_US
dc.relation.ispartof Experimental Brain Research en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Antioxidant enzymes en_US
dc.subject Experimental brain damage en_US
dc.subject Lipid peroxidation en_US
dc.subject Melatonin en_US
dc.subject catalase en_US
dc.subject glutathione en_US
dc.subject glutathione peroxidase en_US
dc.subject malonaldehyde en_US
dc.subject melatonin en_US
dc.subject superoxide dismutase en_US
dc.subject animal model en_US
dc.subject animal tissue en_US
dc.subject antioxidant activity en_US
dc.subject article en_US
dc.subject brain contusion en_US
dc.subject brain injury en_US
dc.subject controlled study en_US
dc.subject craniotomy en_US
dc.subject drug mechanism en_US
dc.subject dura mater en_US
dc.subject enzyme activity en_US
dc.subject enzyme analysis en_US
dc.subject lipid peroxidation en_US
dc.subject male en_US
dc.subject neuroprotection en_US
dc.subject nonhuman en_US
dc.subject oxidative stress en_US
dc.subject priority journal en_US
dc.subject Animals en_US
dc.subject Antioxidants en_US
dc.subject Brain en_US
dc.subject Brain Injuries en_US
dc.subject Catalase en_US
dc.subject Free Radical Scavengers en_US
dc.subject Glutathione Peroxidase en_US
dc.subject Lipid Peroxidation en_US
dc.subject Male en_US
dc.subject Oxidative Stress en_US
dc.subject Rabbits en_US
dc.subject Superoxide Dismutase en_US
dc.title Does melatonin protect or treat brain damage from traumatic oxidative stress? en_US
dc.type Article en_US
dc.identifier.volume 163 en_US
dc.identifier.issue 3 en_US
dc.identifier.startpage 406
dc.identifier.startpage 406 en_US
dc.identifier.endpage 410 en_US
dc.identifier.doi 10.1007/s00221-005-2338-2
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.identifier.pmid 15856200 en_US
dc.identifier.scopus 2-s2.0-23844502311 en_US
dc.identifier.wos WOS:000229617800015 en_US

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