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Platelet-activating factor and P-selectin activities in thrombotic and nonthrombotic Behçet's patients

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dc.contributor.author Tunç, Şevket Ercan
dc.contributor.author Aksu, K.
dc.contributor.author Keser, G.
dc.contributor.author Öksel, Fahrettin
dc.contributor.author Doğanavşargil, Eker
dc.contributor.author Pirildar, T.
dc.contributor.author Turk, T.
dc.contributor.author Terzioglu, E.
dc.contributor.author Huseyinov, A.
dc.date.accessioned 2019-08-16T11:37:57Z
dc.date.available 2019-08-16T11:37:57Z
dc.date.issued 2005
dc.identifier.issn 01728172 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/4847
dc.description.abstract Objective: The aim of this study was to compare plasma Platelet-activating factor (PAF) and P-selectin (CD62P) activities in Behçet's disease patients with and without thrombosis. Methods: In this cross-sectional and descriptive study, 30 consecutive Behçet's patients were included, 15 of them with venous thrombosis. All patients were also divided into two subgroups according to the presence or absence of clinical activity. Plasma PAF levels, basal and Ca++ ionophore (A23187)-induced leukocyte (cellular) PAF activities, and platelet-rich plasma ΔCD62P activity (the mean fluorescent density difference between CD62P phycoerythrin-positive and -negative stains) were evaluated. Results: In the thrombotic group, plasma PAF (P=0.001), basal leukocyte PAF (P=0.017), induced leukocyte PAF (P=0.024), and ΔCD62P (P=0.023) levels were significantly higher than in the nonthrombotic group. In the whole group of Behçet's patients, there was a positive correlation between plasma PAF and ΔCD62P levels (r=0.533, P=0.002). When we compared clinically active and inactive patients with respect to the above parameters, there was no significant difference, irrespective of thrombosis. Plasma PAF (P=0.001), basal leukocyte PAF (P=0.004), and ΔCD62P (P=0.038) levels were significantly higher in the presence of both clinical activity and thrombosis than of clinical activity alone. Conclusion: Platelet-activating factor and CD62P may contribute to endothelial injury and thrombosis development in Behçet's disease. These two parameters seem related to the presence of thrombosis rather than clinical activity. © Springer-Verlag 2004.
dc.language.iso English
dc.relation.isversionof 10.1007/s00296-004-0450-4
dc.rights info:eu-repo/semantics/closedAccess
dc.subject Behçet's disease
dc.subject P-selectin
dc.subject Platelet-activating factor
dc.subject Thrombosis
dc.subject PADGEM protein
dc.subject thrombocyte activating factor
dc.subject article
dc.subject Behcet disease
dc.subject clinical article
dc.subject clinical feature
dc.subject comparative study
dc.subject controlled study
dc.subject correlation analysis
dc.subject deep vein thrombosis
dc.subject disease activity
dc.subject endothelium injury
dc.subject human
dc.subject immunohistochemistry
dc.subject leukocyte
dc.subject lipid blood level
dc.subject priority journal
dc.subject protein function
dc.subject statistical significance
dc.subject vein thrombosis
dc.subject Adult
dc.subject Behcet Syndrome
dc.subject Calcimycin
dc.subject Cells, Cultured
dc.subject Cross-Sectional Studies
dc.subject Female
dc.subject Humans
dc.subject Ionophores
dc.subject Leukocytes
dc.subject Male
dc.subject P-Selectin
dc.subject Platelet Activating Factor
dc.subject Venous Thrombosis
dc.title Platelet-activating factor and P-selectin activities in thrombotic and nonthrombotic Behçet's patients
dc.type Article
dc.relation.journal Rheumatology International
dc.identifier.volume 25
dc.identifier.issue 5
dc.identifier.startpage 326
dc.identifier.endpage 331
dc.relation.publicationCategory Uluslararası Hakemli Dergi
dc.identifier.index Scopus
dc.identifier.index WOS


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